Physical exercise in adolescence changes CB1 cannabinoid receptor expression in the rat brain

Physical exercise in adolescence changes CB1 cannabinoid receptor expression in the rat brain

Author Silva, Sergio Gomes da Autor UNIFESP Google Scholar
Silva Araujo, Bruno Henrique Autor UNIFESP Google Scholar
Cossa, Ana Carolina Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Accumulating evidence indicates that the endocannabinoid system plays an essential role in the development and maturation of the central nervous system. Studies also have demonstrated that neural systems that regulate behavioral responses can be influenced by exercise during development. Exercise and endogenous cannabinoid activity have independently been shown to regulate brain plasticity, hence demonstrating a promising field of the endocannabinoid exercise interaction. in order to investigate whether physical exercise during development would promote changes the brain endocannabinoid system, we investigated the cannabinoid receptor type 1 (CB1) expression in the brain of rats trained during the adolescent period. the results showed that an aerobic exercise program performed during adolescence significantly reduced the CBI receptor expression in the striatum and hippocampal formation. These findings suggest an important link between the endocannabinoid system and physical training in adolescence. (C) 2010 Elsevier B.V. All rights reserved.
Keywords Exercise
Adolescence
Cannabinoid receptor
CB1
Brain
Plasticity
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
INNT
CInAPCe (Brazil)
Date 2010-11-01
Published in Neurochemistry International. Oxford: Pergamon-Elsevier B.V., v. 57, n. 5, p. 492-496, 2010.
ISSN 0197-0186 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 492-496
Origin http://dx.doi.org/10.1016/j.neuint.2010.07.001
Access rights Closed access
Type Article
Web of Science ID WOS:000282472700002
URI http://repositorio.unifesp.br/handle/11600/33046

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