Photorefractive Keratectomy With Mitomycin C After Penetrating and Lamellar Keratoplasty

Photorefractive Keratectomy With Mitomycin C After Penetrating and Lamellar Keratoplasty

Author Forseto, Adriana dos Santos Google Scholar
Marques, Junia Cabral Google Scholar
Nose, Walton Autor UNIFESP Google Scholar
Institution Eye Clin Day Hosp
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: To assess the safety and efficacy of photorefractive keratectomy with mitomycin C (PRK-MMC) to correct refractive errors after corneal transplantation.Methods: This was a prospective and noncomparative study of 36 eyes that underwent PRK-MMC after penetrating (n = 34) or lamellar (n = 2) keratoplasty. After mechanical epithelial removal and photoablation, a sponge with mitomycin C 0.02% was applied to the stromal bed for 1 minute. the uncorrected and best-corrected visual acuities, refraction, and complications were assessed.Results: the average follow-up was 16.27 +/- 8.38 months (range, 6-30.5 months). the spherical equivalent decreased from -3.95 +/- 4.11 to -1.07 +/- 1.45 diopters (D) postoperatively (P < 0.001). the mean preoperative astigmatism was 4.42 +/- 1.69 D (range, 1.00-7.25 D); however, surgical correction was limited to 6.00 D. Vector analysis of astigmatic correction showed an index of success of 55%. At the last follow-up, 41.7% (n = 15) and 61.1% (n = 22) of the eyes were within +/- 0.50 and +/- 1.00 D of emmetropia, respectively. Nineteen eyes (52.8%) achieved an uncorrected visual acuity of 20/40 or better. the best-corrected visual acuity remained within 1 line of the preoperative values in 26 cases (72.2%), improved in 8 (22.2%), and decreased in 2 (5.6%). Endothelial cell decompensation was observed in 1 eye (2.8%) 11 months postoperatively, and haze developed in 3 cases (8.3%).Conclusions: PRK-MMC may be an option to correct refractive errors after keratoplasty. A low preoperative endothelial cell count and haze may affect the safety outcomes.
Keywords astigmatism
photorefractive keratectomy
refractive surgery
Language English
Date 2010-10-01
Published in Cornea. Philadelphia: Lippincott Williams & Wilkins, v. 29, n. 10, p. 1103-1108, 2010.
ISSN 0277-3740 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1103-1108
Access rights Closed access
Type Article
Web of Science ID WOS:000282133100005

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