Parity Is Not Related to Autoimmune Thyroid Disease in a Population-Based Study of Japanese-Brazilians

Parity Is Not Related to Autoimmune Thyroid Disease in a Population-Based Study of Japanese-Brazilians

Author Sgarbi, Jose A. Autor UNIFESP Google Scholar
Kasamatsu, Teresa S. Autor UNIFESP Google Scholar
Matsumura, Luiza K. Autor UNIFESP Google Scholar
Maciel, Rui M. B. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fac Med Marilia
Abstract Background: It has been suggested that the female preponderance for autoimmune thyroid disease might be associated with hormonal differences, abortion, and fetal microchimerism. Findings emerging from the few epidemiological studies on this matter, however, are controversial. in this study, we investigated the hypothesis whether parity, abortion, and the use of estrogens are associated with a higher risk for thyroid autoimmunity.Methods: This cross-sectional population-based study examined 675 women from a Japanese-Brazilian population aged above 30 years. Thyroid peroxidase antibodies (TPOAbs), thyroglobulin antibodies (TgAbs), thyrotropin, and free T(4) were measured by immunofluorimetric assays. Urinary iodine concentration was measured using a colorimetric method. Data were analyzed in logistical regression models to obtain the odds ratio (OR) and 95% confidence intervals.Results: TPOAbs and TgAbs were present in 11.6% and 13.6% of women, respectively. After adjustment for age, smoking, and urinary iodine concentration, the OR for positive TPOAb (OR, 1.22 [95% confidence interval, 0.73-2.02]) and for positive TgAb (OR, 1.01 [0.63-1.62]) among women who had one or more parities did not differ from those who had never given birth. in addition, we found no association between the presence of thyroid antibodies and previous abortions or the use of estrogens.Conclusions: Parity, abortion, and the use of estrogens are not associated with thyroid autoimmunity in this population. These findings reinforce previous reports that advocated against a key role of fetal microchimerism in the pathogenesis of autoimmune thyroid disease.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 06/59737-9
Date 2010-10-01
Published in Thyroid. New Rochelle: Mary Ann Liebert Inc, v. 20, n. 10, p. 1151-1156, 2010.
ISSN 1050-7256 (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert Inc
Extent 1151-1156
Origin http://dx.doi.org/10.1089/thy.2009.0424
Access rights Closed access
Type Article
Web of Science ID WOS:000282363700014
URI http://repositorio.unifesp.br/handle/11600/32967

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