Metformin compared with glyburide for the management of gestational diabetes

Show simple item record Silva, Jean Carl Pacheco, Carina Bizato, Juliana Souza, Barbara Vicente de Ribeiro, Thais Engel Bertini, Anna Maria [UNIFESP] 2016-01-24T14:05:31Z 2016-01-24T14:05:31Z 2010-10-01
dc.identifier.citation International Journal of Gynecology & Obstetrics. Clare: Elsevier B.V., v. 111, n. 1, p. 37-40, 2010.
dc.identifier.issn 0020-7292
dc.description.abstract Objective: To assess blood glucose control and neonatal outcomes when women with gestational diabetes mellitus (GDM) were treated with metformin or glyburide. Methods: When an appropriate diet was insufficient to control their blood glucose levels, women with GDM were randomized to a glyburide or a metformin treatment group. If the maximum dose was reached, the assessed drug was replaced by insulin. the primary outcome measures analyzed were maternal glucose levels during pregnancy, birth weight, and neonatal glucose levels. Results: the only significant difference in outcome between the 2 treatment drugs was that maternal weight gain during pregnancy was less in the metformin (n=40) than in the glyburide group (n=32) (10.3 kg vs 7.6 kg: P=0.02). No differences were found in treatment failure, mean level of fasting or postprandial plasma glucose, rate of participants with glycated hemoglobin, birth weight, rate of large-for-gestational-age newborns, or newborns with hypoglycemia. Conclusion: the treatment of GDM with metformin or glyburide was found to be equivalent for both women and newborns. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. en
dc.format.extent 37-40
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof International Journal of Gynecology & Obstetrics
dc.rights Acesso restrito
dc.subject Gestational diabetes mellitus en
dc.subject Glyburide en
dc.subject Metformin en
dc.subject Treatment en
dc.title Metformin compared with glyburide for the management of gestational diabetes en
dc.type Artigo
dc.contributor.institution Univ Reg Joinville UNIVILLE
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Darcy Vargas Matern Hosp Joinville
dc.contributor.institution Dona Helena Hosp Joinville
dc.contributor.institution UNIMED Hosp Ctr Joinville
dc.description.affiliation Univ Reg Joinville UNIVILLE, Dept Obstet, Joinville, Brazil
dc.description.affiliation São Paulo Fed Univ UNIFESP, Dept Obstet, São Paulo, Brazil
dc.description.affiliation Darcy Vargas Matern Hosp Joinville, Joinville, SC, Brazil
dc.description.affiliation Dona Helena Hosp Joinville, Joinville, SC, Brazil
dc.description.affiliation UNIMED Hosp Ctr Joinville, Joinville, SC, Brazil
dc.description.affiliationUnifesp São Paulo Fed Univ UNIFESP, Dept Obstet, São Paulo, Brazil
dc.identifier.doi 10.1016/j.ijgo.2010.04.028
dc.description.source Web of Science
dc.identifier.wos WOS:000282735100009


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