Flow-through peritoneal dialysis in neonatal enema-induced hyperphosphatemia

Flow-through peritoneal dialysis in neonatal enema-induced hyperphosphatemia

Author Kostic, Dusan Google Scholar
Dutra Rodrigues, Andre Broggin Google Scholar
Leal, Antonio Google Scholar
Metran, Camila Google Scholar
Nagaiassu, Meire Google Scholar
Watanabe, Andreia Google Scholar
Ceccon, Maria Esther Google Scholar
Tannuri, Uenis Google Scholar
Koch, Vera Hermina Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Fleet enemas are hypertonic solutions with an osmotic action and a high concentration of phosphate. When retained in the human body they have a great toxic potential, causing severe hydro-electrolyte disorders in children, especially in newborns. We report the case of a previously healthy 8-day-old newborn who needed neonatal intensive care treatment after the inadvertent administration of an osmotically active hypertonic phosphate enema. Taking into account that phosphate removal by peritoneal dialysis (PD) strongly depends on total dialysate turnover, we chose continuous flow PD (CFPD) as the treatment option, with a successful outcome. Clinical experience with this dialytic modality is limited to a few case reports in pediatric and adult patients. To the best of our knowledge, we report here the first description of CFPD in the setting of acute phosphate nephropathy in the neonatal period. the modality of PD described here has potential as an alternative management option as it is a highly efficient, methodologically simple, and low-cost method without any need for sophisticated equipment. Physicians and parents should be aware of the adverse effects of a hypertonic phosphate enema and should never use these medications in infants and newborns.
Keywords Hyperphosphatemia
Enema
Newborn
Continuous flow peritoneal dialysis
Side effects
Constipation
Language English
Date 2010-10-01
Published in Pediatric Nephrology. New York: Springer, v. 25, n. 10, p. 2183-2186, 2010.
ISSN 0931-041X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 2183-2186
Origin http://dx.doi.org/10.1007/s00467-010-1570-6
Access rights Closed access
Type Article
Web of Science ID WOS:000281110700023
URI http://repositorio.unifesp.br/handle/11600/32942

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