Long-term efficacy of rituximab in hepatitis C virus-associated cryoglobulinemia

Long-term efficacy of rituximab in hepatitis C virus-associated cryoglobulinemia

Author Pereira, Patrícia da Silva Fucuta Autor UNIFESP Google Scholar
Lemos, Lara Barros Autor UNIFESP Google Scholar
Oliveira Uehara, Silvia Naomi de Autor UNIFESP Google Scholar
Souza e Silva, Ivonete Sandra de Autor UNIFESP Google Scholar
Benedito Silva, Antonio Eduardo Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Mixed cryoglobulinemia is one of the most closely related extrahepatic manifestations of hepatitis C virus and requires a challenging therapeutic approach depending on the severity of the symptoms. Here, we describe the long-term follow-up of a patient with important cutaneous, articular and neural manifestations of cryoglobulinemia associated with chronic hepatitis C treated with rituximab. A 42-year-old woman who did not respond to previous interferon-based treatments (standard and pegylated interferon plus ribavirin) and corticosteroids was subjected to treatment with rituximab at a dose of 375 mg/mA(2) per week for 4 consecutive weeks. the drug was well tolerated and complete improvement of arthralgia was immediately evident. There was gradual improvement of lower limbs paresthesia and healing of a leg ulcer that had been active for 5 years. the clinical and immunological responses induced by rituximab are sustained over long-term follow-up, and this case illustrates the drug efficacy for non-responder patients to antiviral therapy.
Keywords Cryoglobulinemia
Hepatitis C virus
Rituximab
Vasculitis
Language English
Date 2010-09-01
Published in Rheumatology International. Heidelberg: Springer Heidelberg, v. 30, n. 11, p. 1515-1518, 2010.
ISSN 0172-8172 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1515-1518
Origin http://dx.doi.org/10.1007/s00296-009-1106-1
Access rights Closed access
Type Article
Web of Science ID WOS:000281254400019
URI http://repositorio.unifesp.br/handle/11600/32864

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