In Vitro Effect of Sulfamethoxazole-Trimethoprim against Histoplasma capsulatum var. capsulatum

In Vitro Effect of Sulfamethoxazole-Trimethoprim against Histoplasma capsulatum var. capsulatum

Author Nogueira Brilhante, Raimunda Samia Google Scholar
Bezerra Fechine, Maria Auxiliadora Google Scholar
Cordeiro, Rossana de Aguiar Google Scholar
Gadelha Rocha, Marcos Fabio Google Scholar
Ribeiro, Joyce Fonteles Google Scholar
Monteiro, Andre Jalles Google Scholar
Chaves de Lima, Rita Amanda Google Scholar
Lima Mesquita, Jaco Ricarte Google Scholar
Camargo, Zoilo Pires de Autor UNIFESP Google Scholar
Costa Sidrim, Jose Julio Google Scholar
Institution Univ Fed Ceara
Univ Estadual Ceara
Universidade Federal de São Paulo (UNIFESP)
Sao Jose Hosp
Abstract This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. the drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number CNPq: 475652/2008-8
Date 2010-09-01
Published in Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 54, n. 9, p. 3978-3979, 2010.
ISSN 0066-4804 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 3978-3979
Origin http://dx.doi.org/10.1128/AAC.00793-10
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000281005900066
URI http://repositorio.unifesp.br/handle/11600/32844

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