MICROCIRCULATORY EVALUATION in SEPSIS: A DIFFICULT TASK

MICROCIRCULATORY EVALUATION in SEPSIS: A DIFFICULT TASK

Author Koh, Ivan H. J. Autor UNIFESP Google Scholar
Díaz, José Luis Menchaca Autor UNIFESP Google Scholar
Koh, Tarso H. Autor UNIFESP Google Scholar
Souza, Ricardo L. Autor UNIFESP Google Scholar
Shu, Christopher M. Autor UNIFESP Google Scholar
Rogerio, Victor E. Autor UNIFESP Google Scholar
Liberatore, Ana M. A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Microcirculatory dysfunction plays a pivotal role in the pathogenesis of severe sepsis and septic shock; hence, microcirculation blood flow monitoring has gained increasing attention. However, microcirculatory imaging is still investigational in human sepsis and has not yet been incorporated into routine clinical practice for several reasons, including the difficult interpretation of microcirculation imaging data, difficulty to draw a parallel between sublingual microcirculation imaging and organ microcirculation dysfunction, as well as the absence of microvessel dysfunction parameters defining sequential microcirculatory changes from the early to late stages of the disease, which could aid in the context of therapeutic approaches and of prognostic parameters. the purpose of this review was to bridge the experimental abdominal organ microvascular derangement kinetics and clinical aspects of microcirculatory findings in the early phase of severe sepsis/septic shock.
Keywords Microcirculation
severe sepsis
septic shock
intravital microscopy
sidestream dark-field imaging
orthogonal polarization spectral imaging
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-09-01
Published in Shock. Philadelphia: Lippincott Williams & Wilkins, v. 34, p. 27-33, 2010.
ISSN 1073-2322 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 27-33
Origin http://dx.doi.org/10.1097/SHK.0b013e3181e7e80c
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000281038500005
URI http://repositorio.unifesp.br/handle/11600/32841

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