Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?

Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?

Author Badiani, Rosilene das Graças Autor UNIFESP Google Scholar
Becker, Vitoria Autor UNIFESP Google Scholar
Perez, Renata de Mello Autor UNIFESP Google Scholar
Matos, Carla Adriana Loureiro de Autor UNIFESP Google Scholar
Lemos, Lara B. Autor UNIFESP Google Scholar
Lanzoni, Valeria Pereira Autor UNIFESP Google Scholar
Andrade, Luis Eduardo C. Google Scholar
Dellavance, Alessandra Google Scholar
Silva, Antonio Eduardo Benedito Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Gomes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Immunol Grp
Abstract AIM: To evaluate the overlap of autoimmune hepatitis in hepatitis C virus (HCV)-infected patients with intense interface hepatitis.METHODS: Among 1759 patients with hepatitis C submitted to liver biopsy, 92 (5.2%) presented intense interface hepatitis. These patients were evaluated regarding the presence of antinuclear antibody (ANA), anti-smooth muscle antibody (SMA) and anti-liver/kidney microsomal antibody (LKM-1), levels of gamma-globulin and histological findings related to autoimmune hepatitis (plasma cell infiltrate and presence of rosettes).RESULTS: Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies (ANA = 12%, SMA = 5%, LKM-1 = 0%) and the median gamma-globulin level was within the normal range. Typical histological findings of autoimmune disease were observed in only two cases (2%). After applying the score for diagnosis of autoimmune hepatitis, only one patient was classified with a definitive diagnosis of autoimmune hepatitis. Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding. the presence of intense interface hepatitis was associated with more advanced age, both at the time of infection and at the time of the biopsy, and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION: Although possible, overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis, an unusual presentation which seems to be related to other host variables. (C) 2010 Baishideng. All rights reserved.
Keywords Hepatitis C
Liver biopsy
Antinuclear antibody
Autoimmune hepatitis
Interface hepatitis
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2010-08-07
Published in World Journal of Gastroenterology. Beijing: W J G Press, v. 16, n. 29, p. 3704-3708, 2010.
ISSN 1007-9327 (Sherpa/Romeo, impact factor)
Publisher W J G Press
Extent 3704-3708
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000280712500013

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