Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

Author Lira, Fabio Santos de Autor UNIFESP Google Scholar
Rosa, Jose C. Autor UNIFESP Google Scholar
Pimentel, Gustavo Duarte Autor UNIFESP Google Scholar
Souza, Helio A. Google Scholar
Caperuto, Erico C. Google Scholar
Carnevali, Luiz C. Google Scholar
Seelaender, Marilia Google Scholar
Damaso, Ana Raimunda Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Santos, Ronaldo V. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Prebiteriana Mackenzie
Abstract Introduction: A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to the development of inflammation by stimulating the secretion of inflammatory factors. This study aimed to examine plasma inflammatory markers and endotoxin levels in individuals with a sedentary lifestyle and/or in highly trained subjects at rest. Methods: Fourteen male subjects (sedentary lifestyle n = 7; highly trained subjects n = 7) were recruited. Blood samples were collected after an overnight fast (similar to 12 h). the plasmatic endotoxin, plasminogen activator inhibitor type-1 (PAI-1), monocyte chemotactic protein-1 (MCP1), ICAM/CD54, VCAM/CD106 and lipid profile levels were determined.Results: Endotoxinemia was lower in the highly trained subject group relative to the sedentary subjects (p < 0.002). in addition, we observed a positive correlation between endotoxin and PAI-1 (r = 0.85, p < 0.0001), endotoxin and total cholesterol (r = 0.65; p < 0.01), endotoxin and LDL-c (r = 0.55; p < 0.049) and endotoxin and TG levels (r = 0.90; p < 0.0001). the plasma levels of MCP-1, ICAM/CD54 and VCAM/CD106 did not differ.Conclusion: These results indicate that a lifestyle associated with high-intensity and high-volume exercise induces favorable changes in chronic low-grade inflammation markers and may reduce the risk for diseases such as obesity, diabetes and cardiovascular diseases.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2008/03533-1
Date 2010-08-04
Published in Lipids in Health and Disease. London: Biomed Central Ltd, v. 9, 5 p., 2010.
ISSN 1476-511X (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 5
Origin http://dx.doi.org/10.1186/1476-511X-9-82
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000283170900001
URI http://repositorio.unifesp.br/handle/11600/32816

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