Chitosan in Nanostructured Thin Films

Chitosan in Nanostructured Thin Films

Author Pavinatto, Felippe J. Google Scholar
Caseli, Luciano Autor UNIFESP Google Scholar
Oliveira, Osvaldo N. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract This review paper brings an overview of the use of chitosans in nanostructured films produced with the Langmuir-Blodgett (LB) or the electrostatic layer-by-layer (LbL) techniques, with emphasis on their possible applications. From a survey in the literature one may identify three main types of study with chitosan in nanostructured films. First, the interaction between chitosans and phospholipid Langmuir monolayers has been investigated for probing the mechanisms of chitosan action in their biological applications, with the monolayers serving as cell membrane models. in the second type, chitosan serves as a matrix for immobilization of biomolecules in LB as well as in LbL films, for which chitosan is suitable to help preserve the bioactivity of such biomolecules for long periods of time even in dry, solid films. An important application of these chitosan-containing films is in sensing and biosensing. the third type of study involves exploiting the mechanical and biocompatibility properties of chitosan in producing films with enhanced properties, for example, for tissue engineering. It is emphasized that chitosans have been proven excellent building blocks to produce films with controlled molecular architecture, allowing for synergy between distinct materials. We also discuss the prospects of the field, following a critical review of the latest developments in nanostructured chitosan films.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2010-08-01
Published in Biomacromolecules. Washington: Amer Chemical Soc, v. 11, n. 8, p. 1897-1908, 2010.
ISSN 1525-7797 (Sherpa/Romeo, impact factor)
Publisher Amer Chemical Soc
Extent 1897-1908
Origin http://dx.doi.org/10.1021/bm1004838
Access rights Closed access
Type Review
Web of Science ID WOS:000280583400001
URI http://repositorio.unifesp.br/handle/11600/32792

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