Photodynamic therapy for acne vulgaris: A critical review from basics to clinical practice Part I. Acne vulgaris: When and why consider photodynamic therapy?

Photodynamic therapy for acne vulgaris: A critical review from basics to clinical practice Part I. Acne vulgaris: When and why consider photodynamic therapy?

Author Sakamoto, Fernanda H. Autor UNIFESP Google Scholar
Lopes, Jose Daniel Autor UNIFESP Google Scholar
Anderson, R. Rox Google Scholar
Institution Harvard Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract The first-line treatments for acne vulgaris are conventional topical and/or oral medications. However, many patients have contraindications, only partial response, significant adverse effects, or recurrence. Light-based treatments and photodynamic therapy (PDT) using topical precursors of porphyrins are off-label alternative treatments for acne vulgaris, with their own advantages and disadvantages. To date, there is no consensus on PDT methodology and parameters. An understanding of pathophysiology of acne, light tissue interactions, and PDT mechanisms of action is helpful whenever PDT is considered as an alternative treatment. in general, blue light alone improves acne because of its antiinflammatory effects. PDT using 5-aminolevulenic acid (ALA) or ALA derivatives induces transient antimicrobial and antiinflammatory effects. At high doses, red light PDT may induce inhibition or destruction of sebaceous glands, resulting in clinical improvement. (J Am Acad Dermatol 2010;63:183-93.)
Keywords 5-aminolevulinic acid
lasers
light
methyl 5-aminolevulinate
photochemotherapy
porphyrins
therapeutics
ultraviolet
Language English
Date 2010-08-01
Published in Journal of the American Academy of Dermatology. New York: Mosby-Elsevier, v. 63, n. 2, p. 183-193, 2010.
ISSN 0190-9622 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 183-193
Origin http://dx.doi.org/10.1016/j.jaad.2009.09.056
Access rights Closed access
Type Article
Web of Science ID WOS:000280252100001
URI http://repositorio.unifesp.br/handle/11600/32780

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