Rest energy expenditure is decreased during the acute as compared to the recovery phase of sepsis in newborns

Rest energy expenditure is decreased during the acute as compared to the recovery phase of sepsis in newborns

Author Feferbaum, Rubens Google Scholar
Leone, Claudio Google Scholar
Siqueira, Arnaldo A. F. Google Scholar
Valenti, Vitor E. Autor UNIFESP Google Scholar
Gallo, Paulo R. Google Scholar
Reis, Alberto O. A. Google Scholar
Lopes, Ary C. Google Scholar
Nascimento, Viviane G. Google Scholar
Oliveira, Adriana G. de Google Scholar
Carvalho, Tatiana Dias de Autor UNIFESP Google Scholar
Wajnsztejn, Rubens Google Scholar
Selestrin, Claudia de Castro Google Scholar
Abreu, Luiz Carlos de Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Fac Med ABC
Abstract Background: Little is known with respect to the metabolic response and the requirements of infected newborns. Moreover, the nutritional needs and particularly the energy metabolism of newborns with sepsis are controversial matter. in this investigation we aimed to evaluate the rest energy expenditure (REE) of newborns with bacterial sepsis during the acute and the recovery phases.Methods: We studied nineteen neonates (27.3 +/- 17.2 days old) with bacterial sepsis during the acute phase and recovery of their illness. REE was determined by indirect calorimetry and VO(2) and VCO(2) measured by gas chromatography.Results: REE significantly increased from 49.4 +/- 13.1 kcal/kg/day during the acute to 68.3 +/- 10.9 kcal/kg/day during recovery phase of sepsis (P < 0.01). Similarly, VO(2) (7.4 +/- 1.9 vs 10 +/- 1.5 ml/kg/min) and VCO(2) (5.1 +/- 1.7 vs 7.4 +/- 1.5 ml/kg/min) were also increased during the course of the disease (P < 0.01).Conclusion: REE was increased during recovery compared to the sepsis phase. REE of septic newborns should be calculated on individualized basis, bearing in mind their metabolic capabilities.
Language English
Sponsor Medical School of University of São Paulo
Date 2010-07-23
Published in Nutrition & Metabolism. London: Biomed Central Ltd, v. 7, 8 p., 2010.
ISSN 1743-7075 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 8
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000282491200002

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