The effect of liposome-delivered prednisolone on collagen density, myofibroblasts, and fibrous capsule thickness around silicone breast implants in rats

The effect of liposome-delivered prednisolone on collagen density, myofibroblasts, and fibrous capsule thickness around silicone breast implants in rats

Author Moreira, Marcio Google Scholar
Fagundes, Djalma José Autor UNIFESP Google Scholar
Simoes, Manuel de Jesus Autor UNIFESP Google Scholar
Taha, Murched Omar Autor UNIFESP Google Scholar
Neves Perez, Luciene Meri Google Scholar
Bazotte, Roberto Barbosa Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Londrina (UEL)
Universidade Estadual de Maringá (UEM)
SBCP
Abstract Capsular contracture is a potential adverse effect of breast implants. An inflammatory reaction is most likely the origin of fibrosis around the implant. It is possible that some substances may act to prevent this inflammatory reaction. Thus, our goal was to evaluate the effectiveness of local depot prednisolone phosphate-liposomes (PPL) on fibrous capsule formation around textured silicone breast implants. Shell prostheses (2 mL) were implanted in the right (plus PPL group) and left (plus saline solution, saline group) subcutaneous dorsum of 18 rats. in another 18 rats, the implants were positioned in the left of the back without any drug instillation (control group). in the PPL group, the capsule thickness (mu m) and density (%) of collagen were significantly (p < 0.0001) lower compared with the control group on days 35 and 90 postsurgery. Furthermore, in the PPL group, a significant reduction in myofibroblast count was observed on day 90 postsurgery (p < 0.0001). in conclusion, a single dose of depot liposome-delivered prednisolone was effective at impairing capsule formation around the silicone implant. the results suggest a strong local and weak systemic effect of PPL on the fibrous tissue around silicone implants. To our knowledge, no study has yet assessed the effect of PPL on silicone breast implants.
Language English
Sponsor Body Medic(TM)
Date 2010-07-01
Published in Wound Repair and Regeneration. Malden: Wiley-Blackwell, v. 18, n. 4, p. 417-425, 2010.
ISSN 1067-1927 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 417-425
Origin http://dx.doi.org/10.1111/j.1524-475X.2010.00601.x
Access rights Closed access
Type Article
Web of Science ID WOS:000279454700083
URI http://repositorio.unifesp.br/handle/11600/32707

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