Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis

Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis

Author Silva Tudesco, Ivanda de Souza Autor UNIFESP Google Scholar
Vaz, Leonardo Jose Autor UNIFESP Google Scholar
Silva Mantoan, Marcele Araujo Autor UNIFESP Google Scholar
Belzunces, Erich Autor UNIFESP Google Scholar
Noffs, Maria Helena Autor UNIFESP Google Scholar
Sales Ferreira Caboclo, Luis Otavio Autor UNIFESP Google Scholar
Targas Yacubian, Elza Marcia Autor UNIFESP Google Scholar
Sakamoto, Americo Ceiki Autor UNIFESP Google Scholar
Amodeo Bueno, Orlando Francisco Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the aim of the present study was to investigate whether working memory is impaired in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), a controversial and largely unexplored matter.Methods: Twenty subjects with left MTLE-HS, 19 with right MTLE-HS, and 21 control right-handed subjects underwent neuropsychological assessment of episodic and semantic memory, executive functions, and specific working memory components.Results: Left and right epileptogenic foci resulted in impairment of verbal and nonverbal episodic memory (verbal memory deficit greater in left MTLE-HS than in right MTLE-HS). in addition, patients with left MTLE-HS were impaired in teaming paired associates, verbal fluency, and Trail Making. No differences were seen in the tests carried out to evaluate the working memory components (except visuospatial short-term memory in right MTLE-HS).Conclusion: in this study we did not detect reliable working memory impairment in patients with MTLE-HS with either a left or right focus in most tasks considered as tests of working memory components. (C) 2010 Elsevier Inc. All rights reserved.
Keywords Working memory
Episodic memory
Semantic memory
Episodic buffer
Sequencing process
Mesial temporal lobe epilepsy
Language English
Sponsor AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2010-07-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 18, n. 3, p. 223-228, 2010.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 223-228
Origin http://dx.doi.org/10.1016/j.yebeh.2010.04.021
Access rights Closed access
Type Article
Web of Science ID WOS:000280259500014
URI http://repositorio.unifesp.br/handle/11600/32689

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