Hippocampal expression and distribution of CB1 receptors in the Amazonian rodent Proechimys: An animal model of resistance to epilepsy

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dc.contributor.author Silva Araujo, Bruno Henrique [UNIFESP]
dc.contributor.author Torres, Laila Brito [UNIFESP]
dc.contributor.author Cossa, Ana Carolina [UNIFESP]
dc.contributor.author Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.author Cavalheiro, Esper Abrao [UNIFESP]
dc.date.accessioned 2016-01-24T13:59:47Z
dc.date.available 2016-01-24T13:59:47Z
dc.date.issued 2010-06-04
dc.identifier http://dx.doi.org/10.1016/j.brainres.2010.03.031
dc.identifier.citation Brain Research. Amsterdam: Elsevier B.V., v. 1335, p. 35-40, 2010.
dc.identifier.issn 0006-8993
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32622
dc.description.abstract Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CBI receptor in the hippocampal formation of Proechimys using immunohistochemistry and Western blotting techniques. Results were compared with values obtained from adult Wistar rats. the immunoreactivity for CB1 was evident throughout the Amman's horn and in the hilar region of both animal species. However, the distribution of these receptors was higher in the stratum lucidum of CA3 and in the hilar region of Proechimys. in addition, higher expression of CB1 receptors was observed in the Proechimys hippocampus. These data could explain, at least partially, the natural resistance of this animal species to developing spontaneous seizures following epileptogenic precipitating events. (C) 2010 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 35-40
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Brain Research
dc.rights Acesso restrito
dc.subject Epilepsy en
dc.subject Epileptogenesis en
dc.subject Proechimys en
dc.subject Cannabinoid receptor 1 (CB1) en
dc.subject Hippocampus en
dc.title Hippocampal expression and distribution of CB1 receptors in the Amazonian rodent Proechimys: An animal model of resistance to epilepsy en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Ctr Nacl Primatas CENP
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Neurol & Neurocirurgia, BR-04023900 São Paulo, Brazil
dc.description.affiliation Ctr Nacl Primatas CENP, IEC, Ananindeua, PA, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Neurol & Neurocirurgia, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/j.brainres.2010.03.031
dc.description.source Web of Science
dc.identifier.wos WOS:000278789400004



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