Hippocampal expression and distribution of CB1 receptors in the Amazonian rodent Proechimys: An animal model of resistance to epilepsy

Hippocampal expression and distribution of CB1 receptors in the Amazonian rodent Proechimys: An animal model of resistance to epilepsy

Author Silva Araujo, Bruno Henrique Autor UNIFESP Google Scholar
Torres, Laila Brito Autor UNIFESP Google Scholar
Cossa, Ana Carolina Autor UNIFESP Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ctr Nacl Primatas CENP
Abstract Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CBI receptor in the hippocampal formation of Proechimys using immunohistochemistry and Western blotting techniques. Results were compared with values obtained from adult Wistar rats. the immunoreactivity for CB1 was evident throughout the Amman's horn and in the hilar region of both animal species. However, the distribution of these receptors was higher in the stratum lucidum of CA3 and in the hilar region of Proechimys. in addition, higher expression of CB1 receptors was observed in the Proechimys hippocampus. These data could explain, at least partially, the natural resistance of this animal species to developing spontaneous seizures following epileptogenic precipitating events. (C) 2010 Elsevier B.V. All rights reserved.
Keywords Epilepsy
Epileptogenesis
Proechimys
Cannabinoid receptor 1 (CB1)
Hippocampus
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2010-06-04
Published in Brain Research. Amsterdam: Elsevier B.V., v. 1335, p. 35-40, 2010.
ISSN 0006-8993 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 35-40
Origin http://dx.doi.org/10.1016/j.brainres.2010.03.031
Access rights Closed access
Type Article
Web of Science ID WOS:000278789400004
URI http://repositorio.unifesp.br/handle/11600/32622

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