Mycobacterium chelonae valve endocarditis resulting from contaminated biological prostheses

Mycobacterium chelonae valve endocarditis resulting from contaminated biological prostheses

Author Strabelli, T. M. V. Google Scholar
Siciliano, Rinaldo Focaccia Google Scholar
Castelli, Jussara Bianchi Google Scholar
Demarchi, L. M. M. F. Google Scholar
Leao, Sylvia Cardoso Autor UNIFESP Google Scholar
Viana-Niero, Cristina Autor UNIFESP Google Scholar
Miyashiro, Kozue Google Scholar
Sampaio, Roney Orismar Google Scholar
Grinberg, Max Google Scholar
Uip, David Everson Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Inst Fleury
Abstract Objectives: A rapid-growing mycobacteria biological prosthetic valve (BPV) endocarditis related to prosthetic manufacturing process is described in Brazil.Methods: From 1999 to 2008, thirty-nine patients underwent BPV replacement due to culture-negative suspected endocarditis. All these cases had histological sections stained by Ziehl-Neelsen method. Clinical and microbiological data were reviewed in all acid-fast bacilli (AFB) positive cases. the 16S-23S internal transcribed sequence (ITS) was amplified using DNA extracted from paraffin-embedded samples, digested with restrictions enzymes and/or sequenced.Results: Eighteen AFB positive BPV (18/39)(46%) were implanted in 13 patients and were from the same manufacturer. Four of them were implanted in other hospitals. Thirteen BPV were histologically proven endocarditis and five showed a colonization pattern. the examination of six non-implanted sterile BPV from this manufacturer resulted in 5 AFB positive. Mycobacterium chelonae was the AFB identified by ITS restriction analysis and sequencing.Conclusions: Rapid-growing mycobacteria infections must be suspected and Ziehl-Neelsen stain always performed on histology of either early or late BPV endocarditis, particularly when blood cultures are negative. (C) 2010 the British Infection Society. Published by Elsevier B.V. All rights reserved.
Keywords Endocarditis
Mycobacterium chelonae
Cardiac valve
Language English
Date 2010-06-01
Published in Journal of Infection. London: W B Saunders Co Ltd, v. 60, n. 6, p. 467-473, 2010.
ISSN 0163-4453 (Sherpa/Romeo, impact factor)
Publisher W B Saunders Co Ltd
Extent 467-473
Access rights Closed access
Type Article
Web of Science ID WOS:000278176200008

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