Antimicrobial Susceptibilities of a Worldwide Collection of Stenotrophomonas maltophilia Isolates Tested against Tigecycline and Agents Commonly Used for S. maltophilia Infections

Antimicrobial Susceptibilities of a Worldwide Collection of Stenotrophomonas maltophilia Isolates Tested against Tigecycline and Agents Commonly Used for S. maltophilia Infections

Author Farrell, David J. Google Scholar
Sader, Helio S. Autor UNIFESP Google Scholar
Jones, Ronald N. Google Scholar
Institution JMI Labs
Universidade Federal de São Paulo (UNIFESP)
Tufts Univ
Abstract Antimicrobial susceptibilities were determined for 1,586 isolates of Stenotrophomonas maltophilia from globally diverse medical centers using the Clinical Laboratory Standards Institute broth microdilution method. the combination trimethoprim-sulfamethoxazole (96.0% of isolates susceptible at <= 2 mu g/ml trimethoprim and 38 mu g/ml sulfamethoxazole) and tigecycline (95.5% of isolates sussceptible at <= 2 mu g/ml) were the only antimicrobials tested with >94% susceptibility in all regions. Susceptibility rates for other commonly used were lower than expected and varied geographically. This in vitro data supports tigecycline as a potential candidate for clinical investigations into S. maltophilia infections.
Language English
Date 2010-06-01
Published in Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 54, n. 6, p. 2735-2737, 2010.
ISSN 0066-4804 (Sherpa/Romeo, impact factor)
Publisher Amer Soc Microbiology
Extent 2735-2737
Origin http://dx.doi.org/10.1128/AAC.01774-09
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000277756000068
URI http://repositorio.unifesp.br/handle/11600/32565

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