Chagas' disease: an update on immune mechanisms and therapeutic strategies

Chagas' disease: an update on immune mechanisms and therapeutic strategies

Author Boscardin, Silvia Beatriz Google Scholar
Troccoli Torrecilhas, Ana Claudia Google Scholar
Manarin, Romina Google Scholar
Revelli, Silvia Google Scholar
Gonzalez Rey, Elena Google Scholar
Tonelli, Renata Rosito Autor UNIFESP Google Scholar
Silber, Ariel Mariano Google Scholar
Institution Universidade de São Paulo (USP)
Mackenzie Presbeterian Univ
Natl Univ Rosario
CSIC
Universidade Federal de São Paulo (UNIFESP)
Abstract The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas' disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. in the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system.
Keywords Chagas' disease
Trypanosoma cruzi
immunity
chemotherapy
immunoparasitology
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Instituto Nacional de Biologia Estrutural e QuImica Medicinal em Doencas Infecciosas (INBEQMeDI)
Grant number FAPESP: 08/57596-4
FAPESP: 07/08648-9
CNPq: 473906/2008-2
Date 2010-06-01
Published in Journal of Cellular and Molecular Medicine. Malden: Wiley-Blackwell, v. 14, n. 6B, p. 1373-1384, 2010.
ISSN 1582-1838 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1373-1384
Origin http://dx.doi.org/10.1111/j.1582-4934.2010.01007.x
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000292023100001
URI http://repositorio.unifesp.br/handle/11600/32564

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