Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy

Show simple item record

dc.contributor.author Piano, Aline de [UNIFESP]
dc.contributor.author Tock, Lian [UNIFESP]
dc.contributor.author Carnier, June [UNIFESP]
dc.contributor.author Oyama, Lila M. [UNIFESP]
dc.contributor.author Oller do Nascimento, Claudia M. [UNIFESP]
dc.contributor.author Comparoni, Aniella [UNIFESP]
dc.contributor.author Foschini, Denis [UNIFESP]
dc.contributor.author Sanches, Priscila L. [UNIFESP]
dc.contributor.author Ernandes, Regina M. Y. [UNIFESP]
dc.contributor.author Mello, Marco Tulio de [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Damaso, Ana R. [UNIFESP]
dc.date.accessioned 2016-01-24T13:59:39Z
dc.date.available 2016-01-24T13:59:39Z
dc.date.issued 2010-05-01
dc.identifier http://dx.doi.org/10.1016/j.metabol.2009.09.003
dc.identifier.citation Metabolism-clinical and Experimental. Philadelphia: W B Saunders Co-Elsevier Inc, v. 59, n. 5, p. 613-619, 2010.
dc.identifier.issn 0026-0495
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32516
dc.description.abstract The complexity pathogenesis in the nonalcoholic fatty liver disease (NAFLD) involves an interplay between adipokines and neuroendocrine regulation of energy balance, including the role of neuropeptide Y (NPY)/agouti-related protein (AgRP) system. the first aim of this study was to assess the effect of long-term interdisciplinary intervention on NAFLD in obese adolescents, and the second objective was to establish the relationship between NPY/AgRP ratio and adiponectinemia. Fifty-five postpuberty obese adolescents were submitted to interdisciplinary intervention. the group was divided between subjects with and without NAFLD (n = 19 and 36, respectively). Blood samples were collected to measure glyccmia, hepatic transaminases, lipid profile, insulin resistance, and sensitivity. Adiponectin, NPY, and AgRP concentrations were measured by enzyme-linked immunosorbent assay. Food intake was measured using 3-day diet records. It was observed at baseline that important clinical parameters including body weight, body mass index, visceral fat, homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index, triglyccrides, very low-density lipoprotein cholesterol, and hepatic transaminases were more altered in NAFLD patients. After the intervention these parameters, total energy, and macronutrient intake were reduced significantly in both groups. the most important finding was the positive correlation between AgRP and visceral fat in all patients and the negative correlation between NPY/AgRP and adiponectinemia only in NAFLD obese adolescents. the NAFLD patients presented more altered clinical parameters than the non-NAFLD subjects, including the negative correlation between adiponectinemia and NPY/AgRP. These results suggested that NAFLD obese adolescents presented an inflammatory profile that can influence the neuroendocrine regulation of energy balance, suggesting an additional impairment in the weight loss therapy. (C) 2010 Elsevier Inc. All rights reserved. en
dc.description.sponsorship AFIP
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship CENESP
dc.description.sponsorship FADA
dc.description.sponsorship UNIFESP-EPM
dc.format.extent 613-619
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Metabolism-clinical and Experimental
dc.rights Acesso restrito
dc.title Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Paulista Med Sch, Postgrad Program Nutr, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Paulista Med Sch, Assoc Found Incent Physicobiol, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Paulista Med Sch, Dept Psychobiol, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Paulista Med Sch, Dept Biosci, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Med Sch, Postgrad Program Nutr, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Med Sch, Assoc Found Incent Physicobiol, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Med Sch, Dept Psychobiol, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Med Sch, Dept Biosci, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2008/53069-0
dc.description.sponsorshipID FAPESP: 2006/00684-3
dc.description.sponsorshipID FAPESP: CEP1D/Sleep 9814303-3 ST
dc.identifier.doi 10.1016/j.metabol.2009.09.003
dc.description.source Web of Science
dc.identifier.wos WOS:000277103700001



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account