Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy

Negative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapy

Author Piano, Aline de Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Oyama, Lila M. Autor UNIFESP Google Scholar
Oller do Nascimento, Claudia M. Autor UNIFESP Google Scholar
Comparoni, Aniella Autor UNIFESP Google Scholar
Foschini, Denis Autor UNIFESP Google Scholar
Sanches, Priscila L. Autor UNIFESP Google Scholar
Ernandes, Regina M. Y. Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Damaso, Ana R. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The complexity pathogenesis in the nonalcoholic fatty liver disease (NAFLD) involves an interplay between adipokines and neuroendocrine regulation of energy balance, including the role of neuropeptide Y (NPY)/agouti-related protein (AgRP) system. the first aim of this study was to assess the effect of long-term interdisciplinary intervention on NAFLD in obese adolescents, and the second objective was to establish the relationship between NPY/AgRP ratio and adiponectinemia. Fifty-five postpuberty obese adolescents were submitted to interdisciplinary intervention. the group was divided between subjects with and without NAFLD (n = 19 and 36, respectively). Blood samples were collected to measure glyccmia, hepatic transaminases, lipid profile, insulin resistance, and sensitivity. Adiponectin, NPY, and AgRP concentrations were measured by enzyme-linked immunosorbent assay. Food intake was measured using 3-day diet records. It was observed at baseline that important clinical parameters including body weight, body mass index, visceral fat, homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index, triglyccrides, very low-density lipoprotein cholesterol, and hepatic transaminases were more altered in NAFLD patients. After the intervention these parameters, total energy, and macronutrient intake were reduced significantly in both groups. the most important finding was the positive correlation between AgRP and visceral fat in all patients and the negative correlation between NPY/AgRP and adiponectinemia only in NAFLD obese adolescents. the NAFLD patients presented more altered clinical parameters than the non-NAFLD subjects, including the negative correlation between adiponectinemia and NPY/AgRP. These results suggested that NAFLD obese adolescents presented an inflammatory profile that can influence the neuroendocrine regulation of energy balance, suggesting an additional impairment in the weight loss therapy. (C) 2010 Elsevier Inc. All rights reserved.
Language English
Sponsor AFIP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
CENESP
FADA
UNIFESP-EPM
Grant number FAPESP: 2008/53069-0
FAPESP: 2006/00684-3
FAPESP: CEP1D/Sleep 9814303-3 ST
Date 2010-05-01
Published in Metabolism-clinical and Experimental. Philadelphia: W B Saunders Co-Elsevier Inc, v. 59, n. 5, p. 613-619, 2010.
ISSN 0026-0495 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 613-619
Origin http://dx.doi.org/10.1016/j.metabol.2009.09.003
Access rights Closed access
Type Article
Web of Science ID WOS:000277103700001
URI http://repositorio.unifesp.br/handle/11600/32516

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