Genetic Analysis of Lrp5 Function in Osteoblast Progenitors

Genetic Analysis of Lrp5 Function in Osteoblast Progenitors

Autor Yadav, Vijay K. Google Scholar
Arantes, Henrique Pierotti Autor UNIFESP Google Scholar
Barros, Elizabete Ribeiro Autor UNIFESP Google Scholar
Lazaretti-Castro, Marise Autor UNIFESP Google Scholar
Ducy, Patricia Google Scholar
Instituição Columbia Univ
Universidade Federal de São Paulo (UNIFESP)
Resumo The low-density lipoprotein receptor-related protein (Lrp)-5 regulates osteoblast proliferation and bone formation through its expression in duodenum by modifying the gut serotonin-bone endocrine axis. However, its direct role, if any, in osteoblast progenitor cells has not been studied thus far. Here, we show that mice with a Dermo1-Cre-mediated disruption of Lrp5 in osteoblast progenitor cells have normal embryonic skeletogenesis and normal skeletal growth and development postnatally. Histomorphometric analysis of 3-month-old adult mice revealed normal osteoblast numbers, bone formation rate, and bone mass in Lrp5 (Dermo) (-/-) mice. in addition, analysis of two osteoporosis pseudoglioma (OPPG) patients revealed a three- to fivefold increase in their serum serotonin levels compared to age-matched controls. These results rule out a direct function of Lrp5 in osteoblast progenitor cells and add further support to the notion that dysregulation of serotonin synthesis is involved in bone mass abnormalities observed in OPPG patients.
Palavra-chave Osteoblast
Osteoporosis
Animal model
Mouse genetics/transgenics
Idioma Inglês
Financiador NIH
IBMS
Data de publicação 2010-05-01
Publicado em Calcified Tissue International. New York: Springer, v. 86, n. 5, p. 382-388, 2010.
ISSN 0171-967X (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 382-388
Fonte http://dx.doi.org/10.1007/s00223-010-9350-7
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000277014000007
Endereço permanente http://repositorio.unifesp.br/handle/11600/32501

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