The integrity of corpus callosum and cluster B personality disorders: A quantitative MRI study in juvenile myoclonic epilepsy

The integrity of corpus callosum and cluster B personality disorders: A quantitative MRI study in juvenile myoclonic epilepsy

Autor Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Lin, Katia Autor UNIFESP Google Scholar
Silva, Ivaldo Autor UNIFESP Google Scholar
Guaranha, Mirian S. B. Autor UNIFESP Google Scholar
Guilhoto, Laura M. F. F. Autor UNIFESP Google Scholar
Carrete Junior, Henrique Autor UNIFESP Google Scholar
Yacubian, Elza Marcia T. Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Evidence suggests increased prevalence of cluster B personality disorders (PD) among patients with juvenile myoclonic epilepsy (JME), which has been associated with worse seizure control and more psychosocial dysfunctions. A preliminary voxel-based morphometry study demonstrated corpus callosum (CC) volume reduction in patients with JME and cluster B PD, particularly in the posterior midbody and isthmus. in this study we aimed to follow up these results with region of interest analysis. Sixteen JME patients with cluster B PD, 38 JME patients without any psychiatric disorder, and 30 demographically matched healthy controls submitted to a psychiatric evaluation and a magnetic resonance imaging scan. the total and regional callosal areas were obtained from the midsagittal slice using a semi-automated program. Psychiatric evaluation was performed through SCID-I and -II. Significant reductions in the posterior region of the CC were observed in the JME with PD group relative to the other groups. These data support previous findings of callosal reductions in cluster B PD, as well as a possible involvement of CC in patients with JME and such personality characteristics. (C) 2010 Elsevier Inc. All rights reserved.
Palavra-chave Cluster B personality disorders
Corpus callosum
Idiopathic generalized epilepsy
Juvenile myoclonic epilepsy
Magnetic resonance imaging
Psychiatric disorders
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2010-04-16
Publicado em Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 34, n. 3, p. 516-521, 2010.
ISSN 0278-5846 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 516-521
Fonte http://dx.doi.org/10.1016/j.pnpbp.2010.02.009
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:000277552300014
Endereço permanente http://repositorio.unifesp.br/handle/11600/32476

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