Repetitive Transcranial Magnetic Stimulation Reduces Cue-Induced Food Craving in Bulimic Disorders

Repetitive Transcranial Magnetic Stimulation Reduces Cue-Induced Food Craving in Bulimic Disorders

Autor Van den Eynde, Frederique Google Scholar
Claudino, Angelica M. Autor UNIFESP Google Scholar
Mogg, Andrew Google Scholar
Horrell, Linda Google Scholar
Stahl, Daniel Google Scholar
Ribeiro, Wagner Autor UNIFESP Google Scholar
Uher, Rudolf Google Scholar
Campbell, Iain Google Scholar
Schmidt, Ulrike Google Scholar
Instituição Kings Coll London
Universidade Federal de São Paulo (UNIFESP)
Resumo Background: Craving or the urge to consume is a characteristic of bulimic eating disorders and addictions. Dysfunction of the dorsolateral prefrontal cortex (DLPFC) is associated with craving. We investigated whether stimulation of the DLPFC reduces food craving in people with a bulimic-type eating disorder.Methods: Thirty-eight people with bulimic-type eating disorders were randomly allocated to receive one session of real or sham high-frequency repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC in a double-blind procedure. Outcome measures included self-reported food craving immediately after the stimulation session and frequency of bingeing over a 24-hour follow-up period.Results: Compared with sham control, real rTMS was associated with decreased self-reported urge to eat and fewer binge-eating episodes over the 24 hours following stimulation.Conclusions: High-frequency rTMS of the left DLPFC lowers cue-induced food cravings in people with a bulimic eating disorder and may reduce binge eating. These results provide a rationale for exploring rTMS as a treatment for bulimic eating disorders.
Palavra-chave Addiction
bingeing
craving
eating disorders
prefrontal cortex
repetitive transcranial magnetic stimulation
Idioma Inglês
Financiador National Institute for Health Research Specialist Biomedical Research Centre for Mental Health
Maudsley National Health Service Foundation Trust
Institute of Psychiatry, King's College London
Marie Curie Research Training Network INTACT (Individually Tailored Stepped Care for Women with Eating Disorders)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Ministry of Education, Brazil
Número do financiamento Marie Curie Research Training Network INTACT (Individually Tailored Stepped Care for Women with Eating Disorders): MRTN-CT-2006-035988
Data de publicação 2010-04-15
Publicado em Biological Psychiatry. New York: Elsevier B.V., v. 67, n. 8, p. 793-795, 2010.
ISSN 0006-3223 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 793-795
Fonte http://dx.doi.org/10.1016/j.biopsych.2009.11.023
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276732600017
Endereço permanente http://repositorio.unifesp.br/handle/11600/32472

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