Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis

Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis

Autor Blaber, Michael Google Scholar
Yoon, Hyesook Google Scholar
Juliano, Maria A. Autor UNIFESP Google Scholar
Scarisbrick, Isobel A. Google Scholar
Blaber, Sachiko I. Google Scholar
Instituição Florida State Univ
Universidade Federal de São Paulo (UNIFESP)
Mayo Clin & Mayo Grad Sch Med
Mayo Grad Sch
Resumo A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. the emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.
Palavra-chave activation cascade
kallikrein
kallikrein-related peptidase (KLK)
plasmin
thrombogenesis
thrombolysis
thrombostasis
Idioma Inglês
Data de publicação 2010-04-01
Publicado em Biological Chemistry. Berlin: Walter de Gruyter & Co, v. 391, n. 4, p. 311-320, 2010.
ISSN 1431-6730 (Sherpa/Romeo, fator de impacto)
Publicador Walter de Gruyter & Co
Extensão 311-320
Fonte http://dx.doi.org/10.1515/BC.2010.024
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276338100003
Endereço permanente http://repositorio.unifesp.br/handle/11600/32462

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