BELATACEPT in CLINICAL and EXPERIMENTAL TRANSPLANTATION - PROGRESS and PROMISE

BELATACEPT in CLINICAL and EXPERIMENTAL TRANSPLANTATION - PROGRESS and PROMISE

Autor Rangel, E. B. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Albert Einstein Hosp
Resumo Belatacept is a fusion protein composed of the Fc fragment of a human IgG(1), immunoglobulin linked to the extracellular domain of cytotoxic T-lymphocyte-associated antigen 4 (CTLA4). CTLA4 is a molecule crucial for T-cell costimulation, selectively blocking the process of T-cell activation. Belatacept binds surface costimulatory ligands (CD80 and CD86) of antigen-presenting cells. Studies on nonhuman primates, as well as phase II and III clinical trials are here reviewed. Belatacept is a promising therapy in organ transplantation and in the future can be used to induce tolerance.
Idioma Inglês
Data de publicação 2010-04-01
Publicado em Drugs of Today. Barcelona: Prous Science, Sa-thomson Reuters, v. 46, n. 4, p. 235-242, 2010.
ISSN 1699-3993 (Sherpa/Romeo, fator de impacto)
Publicador Prous Science, Sa-thomson Reuters
Extensão 235-242
Fonte http://dx.doi.org/10.1358/dot.2010.46.4.1446426
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000279149500001
Endereço permanente http://repositorio.unifesp.br/handle/11600/32461

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