Nuclear Receptor Rev-Erb-alpha Circadian Gene Variants and Lithium Carbonate Prophylaxis in Bipolar Affective Disorder

Nuclear Receptor Rev-Erb-alpha Circadian Gene Variants and Lithium Carbonate Prophylaxis in Bipolar Affective Disorder

Autor Campos-de-Sousa, Sara Google Scholar
Guindalini, Camila Autor UNIFESP Google Scholar
Tondo, Leonardo Google Scholar
Munro, Janet Google Scholar
Osborne, Sarah Google Scholar
Floris, Gianfranco Google Scholar
Pedrazzoli, Mario Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Breen, Gerome Google Scholar
Collier, David Google Scholar
Instituição Kings Coll London
Universidade Federal de São Paulo (UNIFESP)
Lucio Bini Ctr Mood Disorders
Resumo Rev-erb-alpha is one of the key components of the mammalian circadian mechanism; recently, it was also reported to be involved in the biological action of lithium. We investigated whether polymorphisms in the Rev-erb-a gene are associated with the long-term efficacy of lithium carbonate therapy in bipolar affective disorder. Seven single nucleotide polymorphisms (SNPs) were genotyped in a well-characterized sample of patients from Sardinia, Italy, who were followed prospectively for up to 27 years. Genotypic and allelic analysis did not show evidence for association between the polymorphisms and the different levels of lithium response. Further analyses grouping the different levels of response demonstrated that when the patients were separated into groups of nonresponders versus individuals who have had at least a minor or modest improvement in frequency of episodes or admissions, there was a significant increase in the frequency of the T allele in the nonresponder group (p = 0.0008). Logistic regression analyses showed that patients carrying at least one copy of the T allele for the rs2314339 marker were shown to be approximately 3.5 times more likely to have no improvement or even a worsening of the illness (odds ratio [OR], 3.56; 95% confidence interval [CI], 1.18-10.76). the results of this study may help to identify potential biological markers that can serve to predict the response of bipolar affective disorder patients to treatment, improving treatment efficacy.
Palavra-chave bipolar affective disorder
Rev-erb-alpha gene
lithium carbonate therapy
circadian rhythm
sleep
polymorphism
Idioma Inglês
Financiador Stanley Medical Research Institute
Assessorato Sanita Regione Sardegna
Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 98/14303-3
Data de publicação 2010-04-01
Publicado em Journal of Biological Rhythms. Thousand Oaks: Sage Publications Inc, v. 25, n. 2, p. 132-137, 2010.
ISSN 0748-7304 (Sherpa/Romeo, fator de impacto)
Publicador Sage Publications Inc
Extensão 132-137
Fonte http://dx.doi.org/10.1177/0748730410362713
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276010100007
Endereço permanente http://repositorio.unifesp.br/handle/11600/32456

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