Fourier domain optical coherence tomographic and auto-fluorescence findings in indeterminate choroidal melanocytic lesions

Fourier domain optical coherence tomographic and auto-fluorescence findings in indeterminate choroidal melanocytic lesions

Autor Singh, Arun D. Google Scholar
Belfort, Rubens N. Autor UNIFESP Google Scholar
Sayanagi, Kaori Google Scholar
Kaiser, Peter K. Google Scholar
Instituição Cleveland Clin Fdn
Universidade Federal de São Paulo (UNIFESP)
Resumo Aim To compare detection rates of drusen and subretinal fluid by Fourier domain optical coherence tomography (FD OCT) and orange pigment by fundus autofluorescence (FAF) with ophthalmoscopy in indeterminate choroidal melanocytic lesions.Methods in a consecutive case series of 38 patients with indeterminate choroidal melanocytic lesion that would have been categorised as a small tumour according to the size-based nomenclature used in the Collaborative Ocular Melanoma Study, each eye was submitted to ophthalmoscopic examination, FD OCT and FAF. the presence of drusen, subretinal fluid and orange pigment was recorded for each lesion by a single observer at the time of initial ophthalmoscopic evaluation and on fundus photographs. FD OCT and autofluorescence images were reviewed in all cases in a masked fashion.Results the ophthalmoscopic examination revealed drusen in 42%, subretinal fluid in 53% and orange pigment in 50% of patients. FD-OCT detected drusen in 45% and subretinal fluid in 58% of cases, and FAF detected orange pigment in 58% of cases. Based on the McNemar test, none of the differences were statistically significant at the 0.05 level.Conclusions FD OCT and FAF complement clinical examination by verifying and documenting retinal and RPE changes associated with indeterminate choroidal melanocytic lesions. the detection rates by FD OCT and FAF of important qualitative prognostic factors appear to be equivalent to ophthalmoscopy by a trained observer. Once validated in a larger number of patients, FD OCT and FAF findings can be incorporated into diagnostic algorithms.
Idioma Inglês
Data de publicação 2010-04-01
Publicado em British Journal of Ophthalmology. London: B M J Publishing Group, v. 94, n. 4, p. 474-478, 2010.
ISSN 0007-1161 (Sherpa/Romeo, fator de impacto)
Publicador B M J Publishing Group
Extensão 474-478
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276841900018
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