Echocardiographic Parameters and Brain Natriuretic Peptide in Patients after Surgical Repair of Tetralogy of Fallot

Echocardiographic Parameters and Brain Natriuretic Peptide in Patients after Surgical Repair of Tetralogy of Fallot

Autor Tatani, Solange B. Autor UNIFESP Google Scholar
Carvalho, Antonio Carlos C. Autor UNIFESP Google Scholar
Andriolo, Adagmar Autor UNIFESP Google Scholar
Rabelo, Rogerio Google Scholar
Campos, Orlando Autor UNIFESP Google Scholar
Moises, Valdir A. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Inst Fleury
Resumo Background: Although the residual lesions after surgical correction of tetralogy of Fallot (TOF) can be evaluated by Doppler echocardiography (DE), the relation of de parameters with the proBNP level, a potential biomarker of right ventricle overload, is not well known. the objective of this study was to evaluate the de parameters and their relation to proBNP levels. Methods: proBNP plasma level and Doppler echocardiography parameters were obtained on the same day in 49 patients later after repair of TOF (mean age of 14.7 years, 51% female, mean PO time of 9.5 years). the de parameters studied were the dimensions of the right atrium (RA) and ventricle (RV), RV diastolic and systolic function, and residual pulmonary lesions. the relation between them and proBNP levels were analyzed and the cutoff values of de parameters for elevated proBNP determined. Results: proBNP was elevated in 53% and correlated with RV diastolic diameter (r = 0.41; P = 0.003), RA longitudinal (r = 0.52; P = 0.0001) and transversal (r = 0.47; P = 0.001) diameters, pressure half time of pulmonary regurgitation (PR) velocity (PHT) (r = -0.42; P = 0.005), and the PR index (r = -0.60; P < 0.001). By multivariate analysis, the PR index (r = -597; P = 0,001; CI: -913.2 to -280.8) and RA longitudinal (r = 7.74; P < 0,001; CI 4.18 to 11.31) were independent predictors of elevated proBNP. PHT lower than 64 msec (0.76) and PRi lower than 0.65 (0.81) had the best accuracy for elevated proBNP. Conclusion: proBNP may be increased in patients after surgical repair of TOF, correlated with the size of right cardiac chambers and the severity of PR. (Echocardiography 2010;27:442-447).
Palavra-chave tetralogy of Fallot
proBNP
echocardiography
pulmonary regurgitation
Idioma Inglês
Data de publicação 2010-04-01
Publicado em Echocardiography-a Journal of Cardiovascular Ultrasound and Allied Techniques. Malden: Wiley-Blackwell, v. 27, n. 4, p. 442-447, 2010.
ISSN 0742-2822 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 442-447
Fonte http://dx.doi.org/10.1111/j.1540-8175.2009.01032.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276855700016
Endereço permanente http://repositorio.unifesp.br/handle/11600/32453

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