Participation of kinin receptors on memory impairment after chronic infusion of human amyloid-beta 1-40 peptide in mice

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dc.contributor.author Amaral, Fabio Agostini
dc.contributor.author Resk Lemos, Mayra Tolentino
dc.contributor.author Dong, Karis Ester
dc.contributor.author Queiroz Prado Bittencourt, Maria Fernanda
dc.contributor.author Caetano, Ariadiny Lima
dc.contributor.author Pesquero, Joao Bosco [UNIFESP]
dc.contributor.author Viel, Tania Araujo
dc.contributor.author Buck, Hudson Sousa
dc.date.accessioned 2016-01-24T13:59:31Z
dc.date.available 2016-01-24T13:59:31Z
dc.date.issued 2010-04-01
dc.identifier http://dx.doi.org/10.1016/j.npep.2009.10.006
dc.identifier.citation Neuropeptides. Edinburgh: Churchill Livingstone, v. 44, n. 2, p. 93-97, 2010.
dc.identifier.issn 0143-4179
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32424
dc.description.abstract Chronic infusion of human amyloid-beta 1-40 (A beta) in the lateral ventricle (LV) of rats is associated with memory impairment and increase of kinin receptors in cortical and hippocampal areas. Deletion of kinin B1 or B2 receptors abolished memory impairment caused by an acute single injection of A beta in the LV. As brain tissue and kinin receptors could unlikely react to acute or chronic administration of a similar quantity of A beta, we evaluated the participation of B1 or B2 receptors in memory impairment after chronic infusion of A beta. Male C57BI/6 J (wt), knock-out B1 (koB1) or B2 (koB2) mice (12 weeks of age) previously trained in a two-way shuttle-box and achieving conditioned avoidance responses (CAR, % of 50 trials) were infused with AB (550 pmol, 0.12 mu L/h, 28 days) or vehicle in the LV using a mini-osmotic pump. They were tested before the surgery (TO), 7 and 35 days after the infusion started (T7; T35). in T0, no difference was observed between CAR of the control (Cwt = 59.7 +/- 6.7%; CkoB1 = 46.7 +/- 4.0%; CkoB2 = 64.4 +/- 5.8%) and A beta (A beta wt = 66.0 +/- 3.0%; A beta koB1 = 66.8 +/- 8.2%; A beta koB2 = 58.7 +/- 5.9%) groups. in T7, A beta koB2 showed a significant decrease in CAR (41.0 +/- 8.6%) compared to the control-koB2 (72.8 +/- 2.2%, P <0.05). in T35, a significant decrease (P <0.05) was observed in A beta wt (40.7 +/- 3.3%) and A beta koB2 (41.2 +/- 10.7%) but not in the A beta koB1 (64.0 +/- 14.0%) compared to their control groups. No changes were observed in the controls at T35. We suggest that in chronic infusion of BA, B1 receptors could playan important role in the neurodegenerative process. Conversely, the premature memory impairment of koB2 suggests that it may be a protective factor. (C) 2009 Elsevier B.V. All rights reserved. en
dc.format.extent 93-97
dc.language.iso eng
dc.publisher Churchill Livingstone
dc.relation.ispartof Neuropeptides
dc.rights Acesso restrito
dc.subject Bradykinin en
dc.subject Alzheimer en
dc.subject Neurodegeneration en
dc.subject B1 receptor en
dc.subject B2 receptor en
dc.subject Neuroinflammation en
dc.title Participation of kinin receptors on memory impairment after chronic infusion of human amyloid-beta 1-40 peptide in mice en
dc.type Artigo
dc.contributor.institution Fac Ciencies Med Santa Casa São Paulo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Fac Ciencies Med Santa Casa São Paulo, Dept Physiol Sci, BR-01221020 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Arts Sci & Humanities, BR-03828000 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biophys, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biophys, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/j.npep.2009.10.006
dc.description.source Web of Science
dc.identifier.wos WOS:000276001700005



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