Structural and Functional Assessment in HIV-Infected Patients Using Optical Coherence Tomography and Frequency-Doubling Technology Perimetry

Structural and Functional Assessment in HIV-Infected Patients Using Optical Coherence Tomography and Frequency-Doubling Technology Perimetry

Autor Faria e Arantes, Tiago Eugenio Autor UNIFESP Google Scholar
Garcia, Claudio Renato Autor UNIFESP Google Scholar
Arruda Mello, Paulo Augusto de Autor UNIFESP Google Scholar
Muccioli, Cristina Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo PURPOSE: To assess retinal nerve fiber layer (RNFL) and macular thickness using optical coherence tomography (OCT) on HIV-infected patients without ocular manifestations and to correlate these findings with frequency-doubling technology perimetry (FDT).DESIGN: Cross-sectional study.METHODS: SETTING: Single center. STUDY POPULATION: Seventy-three patients (146 eyes) with clinically normal examination classified in 3 groups: group A, HIV-infected patients with CD4 count <100 cells/mm(3) for at least 6 months; group B, HIV-infected patients with CD4 count >100 cells/mm(3) since diagnosis; and group C, HIV-negative control subjects. OBSERVATION PROCEDURES: Fast RNFL and fast macula scan strategies on Stratus OCT and Humphrey Matrix 24-2 full-threshold program. MAIN OUTCOME MEASURES: OCT RNFL and macular thicknesses and FDT indices (mean deviation [MD], pattern standard deviation [PSD], and glaucoma hemifield test [GHT]).RESULTS: Group A had a significantly thinner average RNFL, temporal outer macula, and inferior outer macula thicknesses when compared to groups B and C (P < .05). Statistically significant differences were observed in the FDT MD between groups A and C (P = .034) and in PSD in group A compared to groups B and C (P = .011). Eyes of HIV patients with GHT and PSD results outside normal confidence limits had thinner average RNFL thickness measures than eyes with results within normal limits in the same group of patients (P < .05).CONCLUSIONS: HIV-infected patients with low CD4 count have a significant RNFL and macular thinning. Functional loss detected by FDT is related to RNFL thinning in HIV-infected patients. (Am J Ophthalmol 2010;149: 571-576. (C) 2010 by Elsevier Inc. All rights reserved.)
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data de publicação 2010-04-01
Publicado em American Journal of Ophthalmology. New York: Elsevier B.V., v. 149, n. 4, p. 571-576, 2010.
ISSN 0002-9394 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 571-576
Fonte http://dx.doi.org/10.1016/j.ajo.2009.11.026
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276575700006
Endereço permanente http://repositorio.unifesp.br/handle/11600/32416

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