Low level laser therapy does not modulate the outcomes of a highly bioactive glass-ceramic (Biosilicate(A (R))) on bone consolidation in rats

Low level laser therapy does not modulate the outcomes of a highly bioactive glass-ceramic (Biosilicate(A (R))) on bone consolidation in rats

Autor Oliveira, Poliani Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Pipi, Elaine Favaro Google Scholar
Driusso, Patricia Google Scholar
Parizotto, Nivaldo A. Google Scholar
Muniz Renno, Ana Claudia Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de São Carlos (UFSCar)
Resumo The main purpose of the present work was to evaluate if low level laser therapy (LLLT) can improve the effects of novel fully-crystallized glass-ceramic (Biosilicate(A (R))) on bone consolidation in tibial defects of rats. Forty male Wistar rats with tibial bone defects were used. Animals were divided into four groups: group bone defect control (CG); group bone defect filled with Biosilicate(A (R)) (BG); group bone defect filled with Biosilicate(A (R)), irradiated with LLLT, at 60 J cm(-2) (BG 60) and group bone defect filled with Biosilicate(A (R)), irradiated with LLLT, at 120 J cm(-2) (BG 120). A low-energy GaAlAs 830 nm, CW, 0.6 mm beam diameter, 100 W cm(-2), 60 and 120 J cm(-)A(2) was used in this study. Laser irradiation was initiated immediately after the surgery procedure and it was performed every 48 h for 14 days. Fourteen days post-surgery, the three-point bending test revealed that the structural stiffness of the groups CG and BG was higher than the values of the groups BG60 and BG120. Morphometric analysis revealed no differences between the control group and the Biosilcate(A (R)) group. Interestingly, the groups treated with Biosilicate(A (R)) and laser (BG 60 and BG120) showed statistically significant lower values of newly formed bone in the area of the defect when compared to negative control (CG) and bone defect group filled with Biosilicate (CB). Our findings suggest that although Biosilicate(A (R)) exerts some osteogenic activity during bone repair, laser therapy is not able to modulate this process.
Idioma Inglês
Data de publicação 2010-04-01
Publicado em Journal of Materials Science-materials in Medicine. Dordrecht: Springer, v. 21, n. 4, p. 1379-1384, 2010.
ISSN 0957-4530 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 1379-1384
Fonte http://dx.doi.org/10.1007/s10856-009-3945-4
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276275600038
Endereço permanente http://repositorio.unifesp.br/handle/11600/32415

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