Retinal function in patients treated with tamoxifen

Retinal function in patients treated with tamoxifen

Autor Song Watanabe, Sung Eun Autor UNIFESP Google Scholar
Berezovsky, Adriana Autor UNIFESP Google Scholar
Motono, Marcia Autor UNIFESP Google Scholar
Sacai, Paula Yuri Autor UNIFESP Google Scholar
Pereira, Josenilson Martins Autor UNIFESP Google Scholar
Sallum, Juliana Maria Ferraz Autor UNIFESP Google Scholar
Gebrim, Luiz Henrique Autor UNIFESP Google Scholar
Salomão, Solange Rios Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Tamoxifen, an effective treatment of breast cancer, has been shown to cause ocular toxic effects. the purpose of this study was to determine retinal toxicity by full-field and focal electroretinograms (ERGs) in patients treated with tamoxifen. Full-field and focal ERGs were obtained from three groups: Tamoxifen-14 females (47-72 years, mean 58.3 +/- A 9.1) with normal fundus, treated with tamoxifen from 2 to 37 months; No Treatment-10 females (39-65 years, mean 50.1 +/- A 8.7) with previous breast cancer diagnosis and before tamoxifen treatment; Control-13 normal female volunteers (41-81 years, mean 52.7 +/- A 12.1). Peak-to-peak amplitude and b-wave implicit time were measured and statistically analyzed. Mean peak-to-peak amplitudes and implicit time from full-field and focal ERGs were comparable for the three different groups. Low-dosage tamoxifen showed no retinotoxic effect assessed by full-field and focal ERG in this small group of women with breast cancer.
Palavra-chave Tamoxifen
Retinal toxicity
Electroretinography
Breast cancer
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Número do financiamento FAPESP: 01/03364-6
Data de publicação 2010-04-01
Publicado em Documenta Ophthalmologica. Dordrecht: Springer, v. 120, n. 2, p. 137-143, 2010.
ISSN 0012-4486 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 137-143
Fonte http://dx.doi.org/10.1007/s10633-009-9203-8
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000275526800002
Endereço permanente http://repositorio.unifesp.br/handle/11600/32414

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