Retinal function in patients treated with tamoxifen

Retinal function in patients treated with tamoxifen

Author Song Watanabe, Sung Eun Autor UNIFESP Google Scholar
Berezovsky, Adriana Autor UNIFESP Google Scholar
Motono, Marcia Autor UNIFESP Google Scholar
Sacai, Paula Yuri Autor UNIFESP Google Scholar
Pereira, Josenilson Martins Autor UNIFESP Google Scholar
Sallum, Juliana Maria Ferraz Autor UNIFESP Google Scholar
Gebrim, Luiz Henrique Autor UNIFESP Google Scholar
Salomão, Solange Rios Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Tamoxifen, an effective treatment of breast cancer, has been shown to cause ocular toxic effects. the purpose of this study was to determine retinal toxicity by full-field and focal electroretinograms (ERGs) in patients treated with tamoxifen. Full-field and focal ERGs were obtained from three groups: Tamoxifen-14 females (47-72 years, mean 58.3 +/- A 9.1) with normal fundus, treated with tamoxifen from 2 to 37 months; No Treatment-10 females (39-65 years, mean 50.1 +/- A 8.7) with previous breast cancer diagnosis and before tamoxifen treatment; Control-13 normal female volunteers (41-81 years, mean 52.7 +/- A 12.1). Peak-to-peak amplitude and b-wave implicit time were measured and statistically analyzed. Mean peak-to-peak amplitudes and implicit time from full-field and focal ERGs were comparable for the three different groups. Low-dosage tamoxifen showed no retinotoxic effect assessed by full-field and focal ERG in this small group of women with breast cancer.
Keywords Tamoxifen
Retinal toxicity
Electroretinography
Breast cancer
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 01/03364-6
Date 2010-04-01
Published in Documenta Ophthalmologica. Dordrecht: Springer, v. 120, n. 2, p. 137-143, 2010.
ISSN 0012-4486 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 137-143
Origin http://dx.doi.org/10.1007/s10633-009-9203-8
Access rights Closed access
Type Article
Web of Science ID WOS:000275526800002
URI http://repositorio.unifesp.br/handle/11600/32414

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