Hemoglobin and hematocrit at the end of hemodialysis: a better way to adjust erythropoietin dose?

Hemoglobin and hematocrit at the end of hemodialysis: a better way to adjust erythropoietin dose?

Autor Rangel, Erika B. Autor UNIFESP Google Scholar
Andreoli, Maria Claudia Autor UNIFESP Google Scholar
Matos, Ana Cristina C. Autor UNIFESP Google Scholar
Guimaraes-Souza, Nadia K. Autor UNIFESP Google Scholar
Mallet, Ana Claudia Google Scholar
Carneiro, Fabiana D. Google Scholar
Santos, Bento C. Autor UNIFESP Google Scholar
Instituição Hosp Israelita Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Resumo A severe disadvantage of administration of recombinant human erythropoietin to hemodialysis patients has been reported. A significant correlation has been shown with hemoglobin values determined online by use of the blood volume monitor (BVM) and by laboratory measurement. Online hemoglobin and hematocrit were measured by use of the BVM during hemodialysis session. Data were analyzed by t test and statistical significance was defined as a P of < 0.05. Increases in the mean values of hemoglobin and hematocrit from 11.6 +/- A 1.9 to 13.9 +/- A 2.4 g/dL (17.4 +/- A 7.1%, P = 0.02) and from 34.4 +/- A 6.8 to 42 +/- A 8.3% (20.6 +/- A 8.8%, P = 0.022), respectively, were observed from the beginning to the end of dialysis. We hypothesize that a new strategy for adjusting erythropoietin dose may be based on hemoglobin and hematocrit values evaluated at the end of hemodialysis, when patients are no longer hypervolemic. Inadvertent high levels of hemoglobin could be one explanation why patients present higher rates of cardiovascular and access-related events, especially when monitored online by use of the BVM to achieve the dry weight.
Palavra-chave Blood volume
Erythropoietin
Hemodialysis
Idioma Inglês
Data de publicação 2010-04-01
Publicado em Journal of Artificial Organs. Tokyo: Springer Tokyo, v. 13, n. 1, p. 63-66, 2010.
ISSN 1434-7229 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 63-66
Fonte http://dx.doi.org/10.1007/s10047-010-0484-1
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276264500012
Endereço permanente http://repositorio.unifesp.br/handle/11600/32411

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