Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae)

Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae)

Author Grecco, Simone S. Autor UNIFESP Google Scholar
Reimao, Juliana Q. Google Scholar
Tempone, Andre G. Google Scholar
Sartorelli, Patricia Autor UNIFESP Google Scholar
Romoff, Paulete Google Scholar
Ferreira, Marcelo J. P. Google Scholar
Favero, Oriana A. Google Scholar
Lago, Joao H. G. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Inst Adolfo Lutz Registro
Univ Presbiteriana Mackenzie
Abstract In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4'-methoxyflavanone. the structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Pesquisa e Desenvolvimento
Grant number FAPESP: 06/57626-5
Conselho Nacional de Pesquisa e Desenvolvimento: 473405/2008-3
Conselho Nacional de Pesquisa e Desenvolvimento: 477422/2009-8
Date 2010-04-01
Published in Parasitology Research. New York: Springer, v. 106, n. 5, p. 1245-1248, 2010.
ISSN 0932-0113 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1245-1248
Origin http://dx.doi.org/10.1007/s00436-010-1771-8
Access rights Closed access
Type Article
Web of Science ID WOS:000276234300031
URI http://repositorio.unifesp.br/handle/11600/32409

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