Immunohistochemical Expression of E-cadherin in Sclerosing Adenosis, Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast

Immunohistochemical Expression of E-cadherin in Sclerosing Adenosis, Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast

Author Facina, Gil Autor UNIFESP Google Scholar
Lopes-Costa, Pedro Vitor Google Scholar
Dos Santos, Alesse Ribeiro Google Scholar
De Vasconcelos-Valenca, Rodrigo Jose Google Scholar
Pinho-Sobral, Andre Luis Google Scholar
Ferreira-Filho, Celso Fires Google Scholar
Alencar, Airlane Pereira Google Scholar
Gebrim, Luiz Henrique Autor UNIFESP Google Scholar
Da Silva, Benedito Borges Google Scholar
Institution Univ Fed Piaui
Universidade Federal de São Paulo (UNIFESP)
Abstract E-cadherin (EC) is an important glycoprotein cell-adhesion molecule that appears to play a significant role in the progression of breast lesions. the objective of this study was to evaluate EC expression in sclerosing adenosis, ductal carcinoma in situ and invasive ductal carcinoma. Samples of breast lesions from 44 women were used in this study, comprising cases of sclerosing adenosis (n = 11), ductal carcinoma in situ (DCIS) (n = 10) and invasive ductal carcinoma (n = 23). Immunohistochemical evaluation of EC expression was assessed semiquantitatively and considered negative (<10% of cells with stained cytoplasmic membranes), positive+ (10-50% of cells stained) or positive++ (> 50% of cells stained). Fisher's exact test was used to compare the distribution of staining intensity in the lesions (P < 0.05). There was a progressive loss of EC expression from benign to malignant lesions. This difference was statistically significant when sclerosing adenosis was compared with DCIS (P < 0.0002), when sclerosing adenosis was compared with invasive ductal carcinoma (P < 0.008) and when DCIS was compared with invasive ductal carcinoma (P < 0.007). the present findings point to a significant association between reduced EC expression and the progression and aggressivity of breast lesions. Diagn. Cytopathol. 2010;38:235-238. (C) 2009 Wiley-Liss, Inc.
Keywords E-cadherin
breast
cell adhesion molecule
premalignant lesions
neoplasms
Language English
Date 2010-04-01
Published in Diagnostic Cytopathology. Hoboken: Wiley-liss, v. 38, n. 4, p. 235-238, 2010.
ISSN 8755-1039 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 235-238
Origin http://dx.doi.org/10.1002/dc.21181
Access rights Closed access
Type Article
Web of Science ID WOS:000276114700001
URI http://repositorio.unifesp.br/handle/11600/32398

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