Immunohistochemical Expression of E-cadherin in Sclerosing Adenosis, Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast

Immunohistochemical Expression of E-cadherin in Sclerosing Adenosis, Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast

Autor Facina, Gil Autor UNIFESP Google Scholar
Lopes-Costa, Pedro Vitor Google Scholar
Dos Santos, Alesse Ribeiro Google Scholar
De Vasconcelos-Valenca, Rodrigo Jose Google Scholar
Pinho-Sobral, Andre Luis Google Scholar
Ferreira-Filho, Celso Fires Google Scholar
Alencar, Airlane Pereira Google Scholar
Gebrim, Luiz Henrique Autor UNIFESP Google Scholar
Da Silva, Benedito Borges Google Scholar
Instituição Univ Fed Piaui
Universidade Federal de São Paulo (UNIFESP)
Resumo E-cadherin (EC) is an important glycoprotein cell-adhesion molecule that appears to play a significant role in the progression of breast lesions. the objective of this study was to evaluate EC expression in sclerosing adenosis, ductal carcinoma in situ and invasive ductal carcinoma. Samples of breast lesions from 44 women were used in this study, comprising cases of sclerosing adenosis (n = 11), ductal carcinoma in situ (DCIS) (n = 10) and invasive ductal carcinoma (n = 23). Immunohistochemical evaluation of EC expression was assessed semiquantitatively and considered negative (<10% of cells with stained cytoplasmic membranes), positive+ (10-50% of cells stained) or positive++ (> 50% of cells stained). Fisher's exact test was used to compare the distribution of staining intensity in the lesions (P < 0.05). There was a progressive loss of EC expression from benign to malignant lesions. This difference was statistically significant when sclerosing adenosis was compared with DCIS (P < 0.0002), when sclerosing adenosis was compared with invasive ductal carcinoma (P < 0.008) and when DCIS was compared with invasive ductal carcinoma (P < 0.007). the present findings point to a significant association between reduced EC expression and the progression and aggressivity of breast lesions. Diagn. Cytopathol. 2010;38:235-238. (C) 2009 Wiley-Liss, Inc.
Palavra-chave E-cadherin
breast
cell adhesion molecule
premalignant lesions
neoplasms
Idioma Inglês
Data de publicação 2010-04-01
Publicado em Diagnostic Cytopathology. Hoboken: Wiley-liss, v. 38, n. 4, p. 235-238, 2010.
ISSN 8755-1039 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 235-238
Fonte http://dx.doi.org/10.1002/dc.21181
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276114700001
Endereço permanente http://repositorio.unifesp.br/handle/11600/32398

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