Experimental chronic low-frequency resistance training produces skeletal muscle hypertrophy in the absence of muscle damage and metabolic stress markers

Experimental chronic low-frequency resistance training produces skeletal muscle hypertrophy in the absence of muscle damage and metabolic stress markers

Autor Zanchi, Nelo Eidy Google Scholar
Lira, Fabio Santos Autor UNIFESP Google Scholar
Seelaender, Marilia Google Scholar
Lancha-, Antonio Herbert Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Volitional animal resistance training constitutes an important approach to modeling human resistance training. However, the lack of standardization protocol poses a frequent impediment to the production of skeletal muscle hypertrophy and the study of related physiological variables (i.e., cellular damage/inflammation or metabolic stress). Therefore, the purposes of the present study were: (1) to test whether a long-term and low frequency experimental resistance training program is capable of producing absolute increases in muscle mass; (2) to examine whether cellular damage/inflammation or metabolic stress is involved in the process of hypertrophy. in order to test this hypothesis, animals were assigned to a sedentary control (C, n = 8) or a resistance trained group (RT, n = 7). Trained rats performed 2 exercise sessions per week (16 repetitions per day) during 12 weeks. Our results demonstrated that the resistance training strategy employed was capable of producing absolute mass gain in both soleus and plantaris muscles (12%, p<0.05). Furthermore, muscle tumor necrosis factor (TNF-alpha) protein expression (soleus muscle) was reduced by 24% (p<0.01) in trained group when compared to sedentary one. Finally, serum creatine kinase (CK) activity and serum lactate concentrations were not affected in either group. Such information may have practical applications if reproduced in situations where skeletal muscle hypertrophy is desired but high mechanical stimuli of skeletal muscle and inflammation are not. Copyright (C) 2010 John Wiley & Sons, Ltd.
Palavra-chave Wistar rats
volitional strength exercise
muscle damage
metabolic stress
food reward
low frequency
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 08/51090-1
Data de publicação 2010-04-01
Publicado em Cell Biochemistry and Function. Chichester: John Wiley & Sons Ltd, v. 28, n. 3, p. 232-238, 2010.
ISSN 0263-6484 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 232-238
Fonte http://dx.doi.org/10.1002/cbf.1665
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276875200009
Endereço permanente http://repositorio.unifesp.br/handle/11600/32397

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