Disulfiram impairs the development of behavioural sensitization to the stimulant effect of ethanol

Disulfiram impairs the development of behavioural sensitization to the stimulant effect of ethanol

Autor Kim, Andrezza Kyunmi Autor UNIFESP Google Scholar
Oliveira Souza-Formigoni, Maria Lucia Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: Although disulfiram has been used in the treatment of alcoholism due to the unpleasant sensations its concomitant ingestion with ethanol provokes, some patients reported stimulant effects after its ingestion. This issue has not been addressed in studies with animals. in mice, the stimulant effect of ethanol has been associated with increased locomotor activity and behavioural sensitization. This study sought to analyze the influence of disulfiram on the development of behavioural sensitization to the stimulant effect of ethanol.Methods: Male Swiss mice pre-treated with vehicle or disulfiram (15 mg/kg) received saline or ethanol (2.0 g/kg) every other day, for 5 days. Forty-eight hours afterwards mice were challenged with Saline, and 48 h later they received Disulfiram, or Disulfiram + Ethanol or Ethanol.Results: the co-administration of disulfiram (15 mg/kg) blocked the development of behavioural sensitization induced by ethanol (2.0 g/kg). Although the acute administration of disulfiram did not alter the locomotor activity, its acute administration-induced higher levels of locomotor activity in mice previously sensitized to ethanol than in controls which received saline.Conclusions: Our data suggest that besides the known psychological effects (fear of aversive effects) disulfiram efficacy on alcohol dependency treatment could also be due to its pharmacological interference in the brain neurotransmission. (C) 2009 Elsevier B.V. All rights reserved.
Palavra-chave Ethanol
Disulfiram
Behavioural sensitization
Locomotor activity
Mice
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
AFIP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 04/12448-7
FAPESP: 05/57295-6
Data de publicação 2010-03-05
Publicado em Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 207, n. 2, p. 441-446, 2010.
ISSN 0166-4328 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 441-446
Fonte http://dx.doi.org/10.1016/j.bbr.2009.10.032
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000274761800024
Endereço permanente http://repositorio.unifesp.br/handle/11600/32379

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