Increased MMA concentration and body mass index are associated with spontaneous abortion in Brazilian women A pilot study

Increased MMA concentration and body mass index are associated with spontaneous abortion in Brazilian women A pilot study

Autor Guerra-Shinohara, Elvira M. Google Scholar
Pereira, Perla M. Google Scholar
Kubota, Ananka M. Google Scholar
Silva, Thaiomara A. Google Scholar
Reis, Jucilene L. Google Scholar
Miyashita, Gerson S. Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Allen, Robert H. Google Scholar
Stabler, Sally P. Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Colorado
Resumo Background: the pathophysiology of spontaneous abortion is complex and may involve the interaction of genetic and environmental factors. We evaluated the predictors of spontaneous abortion in Brazilian pregnant women. the effects of age, gestational age. body mass index (BMI), cigarette smoking, alcohol ingestion, use of multivitamins and concentrations of vitamins (folate, cobalamin and vitamin 136) and vitamin-dependent metabolites were analyzed.Methods: Study population included 100 healthy women that attended pre-natal care in 2 health centers of São Paulo, Brazil, and in whom pregnancy outcome was known. Folate and cobalamin status was measured in blood specimens collected between 4 and 16 weeks. the genotypes for 8 gene polymorphisms were evaluated by PCR-RFLP.Results: Eighty-eight women had normal pregnancy outcome (Group 1), while 12 experienced a miscarriage after blood collection (Group 2). Increased methylmalonic acid (MMA) concentrations were found in Group 2 (median [25th-75th percentile]=274 [149-425] nmol/l) relative to Group 1 (138 [98-185]) (P<0.01). No differences between the groups were observed for serum cobalamin, serum or red cell folate, and serum total homocysteine or allele frequencies for 8 polymorphisms. in a conditional logistic regression analysis including age, gestational age, serum creatinine, MMA, cystathionine, body mass index (BMI), cigarette smoking, alcohol ingestion and use of multivitamins the risk of abortion was significantly associated with MMA (OR [95% CI] = 3.80 [1.36, 10.62] per quartile increase in MMA), BMI (OR [95% CI] = 5.49 [1.29,23.39] per quartile) and gestational age (OR [95% CI] = 0.10 [0.01, 0.77] per increase of interval in gestational age).Conclusions: Increased serum MMA and BMI concentrations are associated with spontaneous abortion in Brazilian women. (C) 2009 Elsevier B.V. All rights reserved.
Palavra-chave Cobalamin
Folate
Homocysteine
Methylmalonic acid
Polymorphisms
Body mass index
Spontaneous abortion
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 03/09660-1
FAPESP: 06//06406-5
FAPESP: NIA-AG09834
Data de publicação 2010-03-02
Publicado em Clinica Chimica Acta. Amsterdam: Elsevier B.V., v. 411, n. 5-6, p. 423-427, 2010.
ISSN 0009-8981 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 423-427
Fonte http://dx.doi.org/10.1016/j.cca.2009.12.014
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000275586300021
Endereço permanente http://repositorio.unifesp.br/handle/11600/32378

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