PTPN22 C1858T Polymorphism in Women with Endometriosis

PTPN22 C1858T Polymorphism in Women with Endometriosis

Autor Gomes, Fabiane M. C. S. Google Scholar
Bianco, Bianca Google Scholar
Teles, Juliana S. Google Scholar
Christofolini, Denise M. Google Scholar
Souza, Angela M. B. de Google Scholar
Guedes, Alexis D. Autor UNIFESP Google Scholar
Barbosa, Caio P. Google Scholar
Instituição Universidade Federal do ABC (UFABC)
Universidade Federal de São Paulo (UNIFESP)
Resumo ProblemEndometriosis has been suggested to be an autoimmune disease and recently, an allelic variation of the PTPN22 (C1858T) gene was revealed to be associated with the development of autoimmunity. the aim of the study was to determine the frequency of the PTPN22 (C1858T) polymorphism in Brazilian women with endometriosis as compared with controls.Method of studyCase-control study included 140 women with endometriosis and a control group consisting of 180 healthy fertile women without a history of endometriosis and/or autoimmune diseases from the ABC School of Medicine. the PTPN22 (C1858T) polymorphism was studied by restriction fragment length polymorphism polymerase chain reaction (RFLP-PCR).ResultsGenotypes CC, CT and TT of PTPN22 polymorphism presented frequencies of 67.9, 30.0 and 2.1% in the women with endometriosis (P = 0.008); 76.2, 19.0 and 4.8% in women with minimal/mild endometriosis (P = 0.173); 61.0, 39.0 and 0.0% in women with moderate/severe endometriosis (P < 0.001) and 82.8, 16.1 and 1.1% in control group. Allele C and T were present in 82.9 and 17.1%; 85.7 and 14.3%; 80.5 and 19.5%; and 90.8 and 9.2% respectively, in women with endometriosis (P = 0.004), women with minimal/mild endometriosis (P = 0.148), women with moderate/severe endometriosis (P = 0.002) and control group.ConclusionThe data suggest that in Brazilian women polymorphism PTPN22 (C1858T) may be an important genetic predisposing factor for endometriosis, especially, in advanced disease.
Palavra-chave Autoimmune disease
endometriosis
polymorphism
PTPN22 gene
Idioma Inglês
Data de publicação 2010-03-01
Publicado em American Journal of Reproductive Immunology. Malden: Wiley-Blackwell Publishing, Inc, v. 63, n. 3, p. 227-232, 2010.
ISSN 1046-7408 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 227-232
Fonte http://dx.doi.org/10.1111/j.1600-0897.2009.00797.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000274388000008
Endereço permanente http://repositorio.unifesp.br/handle/11600/32373

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta