Urinary 6-Sulphatoxymelatonin Levels Are Depressed in Chronic Migraine and Several Comorbidities

Urinary 6-Sulphatoxymelatonin Levels Are Depressed in Chronic Migraine and Several Comorbidities

Autor Masruha, Marcelo R. Autor UNIFESP Google Scholar
Lin, Jaime Autor UNIFESP Google Scholar
Souza Vieira, Domingos S. de Google Scholar
Minett, Thais S. C. Autor UNIFESP Google Scholar
Cipolla-Neto, Jose Google Scholar
Zukerman, Eliova Google Scholar
Vilanova, Luiz C. P. Autor UNIFESP Google Scholar
Peres, Mario F. P. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Universidade de São Paulo (USP)
Resumo Objective.-To assess urinary 6-sulphatoxymelatonin levels in a large consecutive series of patients with migraine and several comorbidities (chronic fatigue, fibromyalgia, insomnia, anxiety, and depression) as compared with controls.Background.-Urine analysis is widely used as a measure of melatonin secretion, as it is correlated with the nocturnal profile of plasma melatonin secretion. Melatonin has critical functions in human physiology and substantial evidence points to its importance in the regulation of circadian rhythms, sleep, and headache disorders.Methods.-Urine samples were collected into a single plastic container over a 12-hour period from 8:00 pm to 8:00 am of the next day, and 6-sulphatoxymelatonin was measured by quantitative ELISA. All of the patients were given a detailed questionnaire about headaches and additionally answered the following questionnaires: Chalder fatigue questionnaire, Epworth somnolence questionnaire, State-Trait Anxiety Inventory, and the Beck Depression Inventory.Results.-A total of 220 subjects were evaluated - 73 (33%) had episodic migraine, 73 (33%) had chronic migraine, and 74 (34%) were enrolled as control subjects. There was a strong correlation between the concentration of 6-sulphatoxymelatonin detected and chronic migraine. Regarding the comorbidities, this study objectively demonstrates an inverse relationship between 6-sulphatoxymelatonin levels and depression, anxiety, and fatigue.Conclusions.-To our knowledge, this is the first study to evaluate the relationship between the urinary concentration of melatonin and migraine comorbidities. These results support hypothalamic involvement in migraine pathophysiology.
Palavra-chave pathophysiology
hypothalamus
melatonin
migraine
comorbidities
Idioma Inglês
Data de publicação 2010-03-01
Publicado em Headache. Malden: Wiley-Blackwell Publishing, Inc, v. 50, n. 3, p. 413-419, 2010.
ISSN 0017-8748 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 413-419
Fonte http://dx.doi.org/10.1111/j.1526-4610.2009.01547.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000275097400008
Endereço permanente http://repositorio.unifesp.br/handle/11600/32372

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