Is the geographical origin of a Paracoccidioides brasiliensis isolate important for antigen production for regional diagnosis of paracoccidioidomycosis?

Is the geographical origin of a Paracoccidioides brasiliensis isolate important for antigen production for regional diagnosis of paracoccidioidomycosis?

Autor Batista, Joao Google Scholar
Camargo, Zoilo Pires de Autor UNIFESP Google Scholar
Fernandes, Geisa Ferreira Autor UNIFESP Google Scholar
Vicentini, Adriana Pardini Google Scholar
Fernandes Fontes, Cor Jesus Google Scholar
Hahn, Rosane Christine Google Scholar
Instituição Univ Fed Mato Grosso
Universidade Federal de São Paulo (UNIFESP)
Adolfo Lutz Inst
Resumo P>In this study, exoantigens produced from two Paracoccidioides brasiliensis strains isolated in two different geographical areas were compared in terms of sensitivity and specificity in relation to paracoccidioidomycosis (PCM) diagnosis. Exoantigens from P. brasiliensis 550B (Ag 550B) isolated in the central-west region of Brazil (Mato Grosso State) and exoantigen produced from P. brasiliensis B-339 (Ag B-339) used in reference laboratories were compared by immunodiffusion (ID) tests. When Ag 550B was used in ID test against sera of patients from Mato Grosso and São Paulo, positivity was 92.3% and 41.3%, respectively. On the other hand, when Ag B-339 was tested with the same sera, positivity was 26.2% and 100%, respectively. These results suggest that differences in the antigenic composition probably related to phylogenetic peculiarities in P. brasiliensis isolates from the central-western region of Brazil should be considered in the diagnosis of PCM.
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundacao de Amparo a Pesquisa do Estado de Mato Grosso (FAPEMAT)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2010-03-01
Publicado em Mycoses. Malden: Wiley-Blackwell Publishing, Inc, v. 53, n. 2, p. 176-180, 2010.
ISSN 0933-7407 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 176-180
Fonte http://dx.doi.org/10.1111/j.1439-0507.2008.01687.x
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000274412300014
Endereço permanente http://repositorio.unifesp.br/handle/11600/32370

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