HIV Type 1 Antiretroviral Resistance Mutations in Subtypes B, C, and F in the City of São Paulo, Brazil

HIV Type 1 Antiretroviral Resistance Mutations in Subtypes B, C, and F in the City of São Paulo, Brazil

Autor Munerato, Patricia Autor UNIFESP Google Scholar
Sucupira, Maria Cecilia Autor UNIFESP Google Scholar
Oliveros, Marcia P. R. Autor UNIFESP Google Scholar
Janini, Luiz Mario Google Scholar
Souza, Denise Ferreira de Google Scholar
Pereira, Anderson Alvarenga Google Scholar
Inocencio, Lilian Amaral Google Scholar
Diaz, Ricardo Sobhie Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Brazilian Natl Minist Hlth
Resumo In Brazil, where three distinct HIV-1 subtypes ( B, F, and C) cocirculate, a significant portion of the HIV-infected population has been exposed to antiretroviral drugs. This study analyzes the antiretroviral resistance profiles of HIV-1-infected individuals failing antiretroviral therapy. Genotypic resistance profiles of 2474 patients presenting virologic failure to antiretroviral therapy in the city of São Paulo, Brazil, were generated and analyzed. Resistance mutations to protease inhibitors and nucleoside reverse transcriptase inhibitors were less common in subtype C viruses, whereas nonnucleoside reverse transcriptase inhibitor resistance mutations were less common in subtype F viruses. the thymidine analog mutation pathway known as pathway 1 was more prevalent in subtype B viruses than in subtype C viruses, whereas pathway 2 was more prevalent in subtype C viruses. Selected resistance mutations varied according to subtype for all three classes of antiretrovirals. We describe two distinct pathways of nonnucleoside reverse transcriptase inhibitor resistance ( to nevirapine and efavirenz). Although cross-resistance to etravirine should occur more frequently among individuals failing nevirapine treatment, the prevalence of cross-resistance to etravirine, darunavir, and tipranavir was found to be low. We found that increases in the number of resistance mutations will be related to increases in the viral load. Special attention should be given to resistance profiles in non-B subtype viruses. the accumulation of knowledge regarding such profiles in the developing world is desirable.
Idioma Inglês
Data de publicação 2010-03-01
Publicado em Aids Research and Human Retroviruses. New Rochelle: Mary Ann Liebert Inc, v. 26, n. 3, p. 265-273, 2010.
ISSN 0889-2229 (Sherpa/Romeo, fator de impacto)
Publicador Mary Ann Liebert Inc
Extensão 265-273
Fonte http://dx.doi.org/10.1089/aid.2009.0288
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000275983300002
Endereço permanente http://repositorio.unifesp.br/handle/11600/32363

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