The sleep-wake cycle in adult rats following pilocarpine-induced temporal lobe epilepsy

The sleep-wake cycle in adult rats following pilocarpine-induced temporal lobe epilepsy

Author Matos, Gabriela Google Scholar
Tsai, Rodrigo Google Scholar
Baldo, Marcus Vinicius Google Scholar
Castro, Isac de Autor UNIFESP Google Scholar
Sameshima, Koichi Google Scholar
Valle, Angela Cristina Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Abstract The relationship between sleep and epilepsy is both complex and clinically significant. Temporal lobe epilepsy (TLE) influences sleep architecture, while sleep plays an important role in facilitating and/or inhibiting possible epileptic seizures. the pilocarpine experimental model reproduces several features of human temporal lobe epilepsy and is one of the most widely used models in basic research. the aim of the present study was to characterize, behaviorally and electrophysiologically, the phases of sleep-wake cycles (SWC) in male rats with pilocarpine-induced epilepsy. Epileptic rats presented spikes in all phases of the SWC as well as atypical cortical synchronization during attentive wakefulness and paradoxical sleep. the architecture of the sleep-wake phases was altered in epileptic rats, as was the integrity of the SWC. Because our findings reproduce many relevant features observed in patients with epilepsy, this model is suitable to study sleep dysfunction in epilepsy. (C) 2009 Elsevier Inc. All rights reserved.
Keywords Sleep-wake cycle
Status epilepticus
Language English
Date 2010-03-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 17, n. 3, p. 324-331, 2010.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 324-331
Access rights Closed access
Type Article
Web of Science ID WOS:000276029900004

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