The sleep-wake cycle in adult rats following pilocarpine-induced temporal lobe epilepsy

The sleep-wake cycle in adult rats following pilocarpine-induced temporal lobe epilepsy

Autor Matos, Gabriela Google Scholar
Tsai, Rodrigo Google Scholar
Baldo, Marcus Vinicius Google Scholar
Castro, Isac de Autor UNIFESP Google Scholar
Sameshima, Koichi Google Scholar
Valle, Angela Cristina Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The relationship between sleep and epilepsy is both complex and clinically significant. Temporal lobe epilepsy (TLE) influences sleep architecture, while sleep plays an important role in facilitating and/or inhibiting possible epileptic seizures. the pilocarpine experimental model reproduces several features of human temporal lobe epilepsy and is one of the most widely used models in basic research. the aim of the present study was to characterize, behaviorally and electrophysiologically, the phases of sleep-wake cycles (SWC) in male rats with pilocarpine-induced epilepsy. Epileptic rats presented spikes in all phases of the SWC as well as atypical cortical synchronization during attentive wakefulness and paradoxical sleep. the architecture of the sleep-wake phases was altered in epileptic rats, as was the integrity of the SWC. Because our findings reproduce many relevant features observed in patients with epilepsy, this model is suitable to study sleep dysfunction in epilepsy. (C) 2009 Elsevier Inc. All rights reserved.
Palavra-chave Sleep-wake cycle
Epilepsy
Pilocarpine
Status epilepticus
Seizures
Idioma Inglês
Data de publicação 2010-03-01
Publicado em Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 17, n. 3, p. 324-331, 2010.
ISSN 1525-5050 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 324-331
Fonte http://dx.doi.org/10.1016/j.yebeh.2009.11.015
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276029900004
Endereço permanente http://repositorio.unifesp.br/handle/11600/32359

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