Effects of L-Nitro-Arginine Methyl Ester, an Inhibitor of Nitric Oxide Biosynthesis, on Intestinal Ischemia/Reperfusion Injury in Rabbits

Effects of L-Nitro-Arginine Methyl Ester, an Inhibitor of Nitric Oxide Biosynthesis, on Intestinal Ischemia/Reperfusion Injury in Rabbits

Autor Taha, M. O. Autor UNIFESP Google Scholar
Miranda-Ferreira, R. Google Scholar
Fagundes, A. L. Google Scholar
Fagundes, D. J. Google Scholar
Simoes, R. S. Google Scholar
Santos, J. M. Google Scholar
Souza, P. D. F. Google Scholar
Oliveira-Júnior, Itamar Souza Autor UNIFESP Google Scholar
Marchini, A. Google Scholar
Gomes, I. T. Google Scholar
Monteiro, H. P. Google Scholar
Mendonca, L. O. Google Scholar
Caricati-Neto, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UFGD
Resumo To study whether treatment with L-nitro-arginine methyl ester (L-NAME), an inhibitor of nitric oxide biosynthesis, attenuates intestinal dysfunction caused by ischemia (I) and/or reperfusion (R), rabbits were treated with L-NAME (15 mg . kg(-1), intervenously) or saline olution (SS) prior to I (60 minutes) induced by occlusion of superior mesenteric artery and/or R (120 minutes). After I or I/R, isolated jejunal segments (2 cm) were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KCI using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for analysis by optical microscopy. Compared with a sham group, the jejunal contractions were similar in the I/R + L-NAME, but reduced in I + SS, I/R + SS, and I + L-NAME groups. the jejunal enteric nerves were damaged in the I + SS, I/R + SS, and I + L-NAME cohorts, but not among the I/R + L-NAME cohort. These results suggested that L-NAME attenuated intestinal dysfunction caused by R but not by I.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2010-03-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 42, n. 2, p. 457-460, 2010.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 457-460
Fonte http://dx.doi.org/10.1016/j.transproceed.2010.01.037
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276051400014
Endereço permanente http://repositorio.unifesp.br/handle/11600/32353

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