Effects of 5 '-Adenosine Triphosphate on Intestinal Ischemia-Reperfusion in Rabbits

Effects of 5 '-Adenosine Triphosphate on Intestinal Ischemia-Reperfusion in Rabbits

Autor Taha, M. O. Autor UNIFESP Google Scholar
Miranda-Ferreira, R. Google Scholar
Fagundes, D. J. Google Scholar
Simoes, R. S. Google Scholar
Monteiro, H. P. Google Scholar
Oliveira-Júnior, Itamar Souza Autor UNIFESP Google Scholar
Soares, K. R. M. Google Scholar
Martins, M. C. L. Google Scholar
Balbino, A. T. Google Scholar
Rodrigues, F. F. Google Scholar
Arruda, T. B. Google Scholar
Abrao, M. S. Google Scholar
Jurkiewicz, A. Google Scholar
Caricati-Neto, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UFGD
Resumo To study whether treatment with 5'-adenosine triphosphate (ATP), an agonist of P2 purine receptors, attenuated intestinal dysfunction caused by ischemia (I) and/or reperfusion (R), rabbits were treated with ATP (15 mg . kg(-1), intravenously) or saline solution (SS) 60 minutes before I by occlusion of the superior mesenteric artery and/or R (120 minutes). After I or I/R isolated 2-cm jejunal segments were mounted in an organ bath to study nerve-mediated contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained (hematoxylin and eosin) for optical microscopy. Compared to a sham group, the jejunal contractions were similar to sham hosts among I + ATP, but reduced in I + SS, I/R + SS, and I/R + ATP groups. the jejunal-enteric nerves were damaged in I + SS, I/R + SS, and I/R + ATP, but not the I + ATP group. These results suggested that ATP attenuated intestinal dysfunction produced by I, but not that caused by R.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2010-03-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 42, n. 2, p. 461-464, 2010.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 461-464
Fonte http://dx.doi.org/10.1016/j.transproceed.2010.01.036
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276051400015
Endereço permanente http://repositorio.unifesp.br/handle/11600/32352

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta