Leishmania (Leishmania) amazonensis Infection in Mice Treated With FTY720

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dc.contributor.author Lopes, C. T. [UNIFESP]
dc.contributor.author De Paula, Daisy Maria Bentes [UNIFESP]
dc.contributor.author Cury, P. M.
dc.contributor.author Valero-Lapchik, V. B. [UNIFESP]
dc.contributor.author Bueno, V. [UNIFESP]
dc.date.accessioned 2016-01-24T13:59:25Z
dc.date.available 2016-01-24T13:59:25Z
dc.date.issued 2010-03-01
dc.identifier http://dx.doi.org/10.1016/j.transproceed.2010.01.026
dc.identifier.citation Transplantation Proceedings. New York: Elsevier B.V., v. 42, n. 2, p. 578-581, 2010.
dc.identifier.issn 0041-1345
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32350
dc.description.abstract In transplantation, parasite diseases are transmitted from the donor, or appear as de novo infections, or activate from a dormant insource as a consequence of immunosuppression. Clinical findings have shown that an intact immune system is crucial to prevent recurrence of Leishmania infection. We used BALB/c and C57BL/6 mice to evaluate the role of FTY720 in leishmaniasis. Mice inoculated with Leishmania (Leishmania) amazonensis were followed over 71/2 weeks for foot thickness measurements after initiation of FTY720 treatment. After 10 days of treatment, spleen, blood, and the foot were harvested for evaluation. BALB/c showed greater evident foot thickness than C57BL/6 mice. Oral treatment with FTY720 (1 mg/kg/d) over 10 days produced the same outcome. Increases in CD4(+) and CD8(+) T cells were observed after infection; FTY720 treatment was associated with a decrease in CD4(+) T cells only in BALB/c mice, whereas CD8(+) T cells were decreased in both mice strains. CD11b(+) expression decreased after infection with a discrete increase after FTY720 treatment. Lymphopenia was observed among all FTY720-treated mice. in conclusion, we observed that FTY720 produced no worse an outcome as monotherapy in established infections with L (L) amazonensis. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 578-581
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Transplantation Proceedings
dc.rights Acesso restrito
dc.title Leishmania (Leishmania) amazonensis Infection in Mice Treated With FTY720 en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Med, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Inst Pharmacol, BR-04023900 São Paulo, Brazil
dc.description.affiliation Med Sch Sao Jose do Rio Preto FAMERP, Dept Pathol, Sao Jose Do Rio Preto, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Med, Div Nephrol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Inst Pharmacol, BR-04023900 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 04/14727-0
dc.description.sponsorshipID FAPESP: 07/56901-5
dc.identifier.doi 10.1016/j.transproceed.2010.01.026
dc.description.source Web of Science
dc.identifier.wos WOS:000276051400046



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