Leishmania (Leishmania) amazonensis Infection in Mice Treated With FTY720

Leishmania (Leishmania) amazonensis Infection in Mice Treated With FTY720

Autor Lopes, C. T. Autor UNIFESP Google Scholar
De Paula, Daisy Maria Bentes Autor UNIFESP Google Scholar
Cury, P. M. Google Scholar
Valero-Lapchik, V. B. Autor UNIFESP Google Scholar
Bueno, V. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo In transplantation, parasite diseases are transmitted from the donor, or appear as de novo infections, or activate from a dormant insource as a consequence of immunosuppression. Clinical findings have shown that an intact immune system is crucial to prevent recurrence of Leishmania infection. We used BALB/c and C57BL/6 mice to evaluate the role of FTY720 in leishmaniasis. Mice inoculated with Leishmania (Leishmania) amazonensis were followed over 71/2 weeks for foot thickness measurements after initiation of FTY720 treatment. After 10 days of treatment, spleen, blood, and the foot were harvested for evaluation. BALB/c showed greater evident foot thickness than C57BL/6 mice. Oral treatment with FTY720 (1 mg/kg/d) over 10 days produced the same outcome. Increases in CD4(+) and CD8(+) T cells were observed after infection; FTY720 treatment was associated with a decrease in CD4(+) T cells only in BALB/c mice, whereas CD8(+) T cells were decreased in both mice strains. CD11b(+) expression decreased after infection with a discrete increase after FTY720 treatment. Lymphopenia was observed among all FTY720-treated mice. in conclusion, we observed that FTY720 produced no worse an outcome as monotherapy in established infections with L (L) amazonensis.
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do financiamento FAPESP: 04/14727-0
FAPESP: 07/56901-5
Data 2010-03-01
Publicado em Transplantation Proceedings. New York: Elsevier B.V., v. 42, n. 2, p. 578-581, 2010.
ISSN 0041-1345 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 578-581
Fonte http://dx.doi.org/10.1016/j.transproceed.2010.01.026
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000276051400046
URI http://repositorio.unifesp.br/handle/11600/32350

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