Sirolimus in Combination With FTY720: Analysis of Urinary and Serum Parameters

Sirolimus in Combination With FTY720: Analysis of Urinary and Serum Parameters

Author Lopes, C. T. Autor UNIFESP Google Scholar
Pletiskaitz, Thaís Maria da Fonseca Autor UNIFESP Google Scholar
Franco, M. F. de Autor UNIFESP Google Scholar
Cordeiro, J. A. Google Scholar
Bueno, V. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The goal in transplantation is to obtain immunosuppressant combinations that decrease the incidence of acute and chronic rejection but cause fewer side effects. FTY720 is a new immunomodulator that prevents experimental allograft rejection without inhibiting T-cell activation. It is currently under clinical investigation for multiple sclerosis. We investigated whether FTY720 in combination with sirolimus (SRL) could cause renal toxicity in C57BL/6 mice when administered for 21 days. Serum creatinine and 24-hour urinary creatinine concentrations were assessed by enzymatic colorimetric assays. Urinary protein concentration was measured by the Bradford protein assay. Whereas serum creatinine levels were increased in FTY720 + SRL-treated animals, there were no changes in urinary volume, urinary protein levels, serum urea concentration, creatinine clearance, and kidney structure. Our findings suggested that FTY720 monotherapy for multiple sclerosis and other diseases could play an important immunomodulatory role without causing the side effects frequently observed with other transplantation regimens.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 04/14727-0
FAPESP: 07/56901-5
Date 2010-03-01
Published in Transplantation Proceedings. New York: Elsevier B.V., v. 42, n. 2, p. 582-584, 2010.
ISSN 0041-1345 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 582-584
Access rights Closed access
Type Article
Web of Science ID WOS:000276051400047

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